肠道菌群失调与血管内皮损伤的相关机制研究概况

Survey of the research on the related mechanisms of intestinal microflora imbalance involved in vascular endothelial injury

摘要:

肠道菌群是一个具有调控机体屏障、调节代谢活动等功能的重要微生物群。近年来研究发现，肠道菌群紊乱与多种疾病相关。肠道菌群及其代谢产物的失调可能会引起血管内皮炎症、氧化应激等，可能是血管内皮损伤的重要因素之一。该文综述近年来肠道菌群在血管内皮损伤中的作用机制及相关治疗方法，为优化心血管疾病的治疗策略提供新的理论参考。

Abstract:

Recent studies have shown that gut microbiota has important physiological functions such as regulating body barriers and influencing metabolic activities, and is also an important pathogenic factor and regulatory medium. Endothelial cells play an important role in the pathogenesis of vascular diseases. Endothelial damage is a risk factor for cardiovascular diseases. Disturbance of gut microbiota is related to various diseases, and the imbalance of gut microbiota and its metabolites mediates the inflammation and oxidative stress state of vascular endothelium, inducing vascular endothelial damage. This article reviews the mechanism of the involvement of gut microbiota in vascular endothelial injury and related intervention strategies, providing new ideas and directions for the intervention of vascular endothelial injury from the perspective of gut microbiota and its downstream.