m6A甲基化修饰蛋白在卵巢癌中的研究进展

Advances in roles of m6A regulators in ovarian cancer

摘要:

N6-甲基腺苷（m6A）是一种广泛存在于肿瘤细胞中的表观遗传学修饰，为动态、可逆性修饰mRNA。卵巢癌是妇科癌症中病死率最高的恶性肿瘤。m6A甲基化修饰蛋白的高表达或低表达会促进或抑制卵巢癌，但其具体机制尚未完全明确。因此，探究m6A修饰蛋白对卵巢癌进展的影响将为卵巢癌的早期诊断及治疗提供帮助。该文就近年来m6A修饰蛋白对卵巢癌的增殖、转移的影响及其机制研究作一综述。

Abstract:

N6-methyladenosine (m6A) is an epigenetic modification widely existing in tumor cells that dynamically and reversibly modifies mRNA. Ovarian cancer is the malignant tumor with the highest mortality among gynecological cancers. High or low expressions of m6A regulators may lead to the promotion or inhibition of ovarian cancer development and progression, but the specific mechanism has not been fully elucidated. Therefore, to explore the effects of m6A regulators on the progression of ovarian cancer will facilitate the early diagnosis and treatment of ovarian cancer. This review summarizes the advances in the effects of m6A regulators on proliferation and metastasis of ovarian cancer as well as the underlying mechanisms thereof in recent years.