下丘脑Kiss1系统在产前应激诱导男性后代生殖功能异常中的潜在作用

Potential roles of the hypothalamic KiSS1 system in prenatal stress-induced reproductive dysfunction in male offspring

摘要:

下丘脑Kiss1系统是下丘脑-垂体-性腺轴中的一个重要组成部分，其通过促进促性腺激素释放激素的分泌，来调节生殖功能。最近研究发现，产前应激对男性后代生殖功能具有影响。然而，产前应激诱导的男性后代生殖功能下降的机制仍未阐明。通过对下丘脑Kiss1系统的治疗可能改善产前应激，诱导男性后代的生殖功能，该综述将讨论下丘脑Kiss1系统在产前应激诱导男性后代生殖功能异常中的潜在作用。

Abstract:

The hypothalamic KiSS1 system is an essential component of the hypothalamic-pituitary-gonadal axis, and regulates the reproductive function by promoting the secretion of gonadotropin hormone-releasing hormone (GnRH). Recent studies have identified the effects of prenatal stress on the reproductive function of male offspring. However, the mechanisms underlying the prenatal stress-induced decline in reproductive function in male offspring remain elusive. Treatment targeting the hypothalamic KiSS1 system may improve the reproductive function of prenatally stressed male offspring. This review will discuss the potential roles of the KiSS1 system in prenatal stress-induced reproductive dysfunction in male offspring.