男性雄激素影响血管内皮细胞机制的研究进展

Research progress on the mechanism of male androgens affecting vascular endothelial cells

摘要:

雄激素是体内决定男性特征的最重要物质，其生理作用贯穿男性生命周期的全部生理活动。血管内皮细胞损伤参与心血管、男性生殖等慢性疾病的发生、发展。雄激素主要通过结合雄激素受体影响血管内皮细胞功能，亦可转化为雌激素发挥部分作用，其主要途径是调节炎症反应、氧化应激、细胞增殖、细胞凋亡、细胞迁移及血脂代谢。生理量雄激素具有保护作用，其水平异常则表现损害作用。该文综述雄激素调节血管内皮细胞功能的作用与机制，以期为防治相关疾病提供参考。

Abstract:

Androgens is the most important substance determining male characteristics in the body, and its physiological effects span all stages of male life. Endothelial cell damage is involved in the occurrence and development of various chronic diseases such as cardiovascular diseases and male reproductive disorders. Androgens mainly affects endothelial cell function by binding to the androgen receptor, and can also be converted to estrogen to exert partial effects. Its main pathways include regulating inflammation, oxidative stress, cell proliferation, apoptosis and migration, and lipid metabolism. Physiological levels of androgens have a protective effect, while abnormal levels may have damaging effects. This article reviews the role and mechanisms of androgens in regulating endothelial cell function, aiming to provide references for the prevention and treatment of related diseases.