牛磺酸代谢在抗肿瘤领域的研究进展

Research progress of taurine metabolism in cancer

摘要:

近年来免疫治疗的发展改变了癌症治疗模式，然而，单药免疫治疗有效率低，通过联合化疗、靶向治疗等改变肿瘤微环境能够大大提高其疗效。其中，氨基酸代谢，尤其是牛磺酸代谢可能通过肿瘤微环境的代谢重编程协同增强免疫治疗疗效。该文具体讨论了牛磺酸调控肿瘤微环境和肿瘤细胞代谢的潜在机制，可能为肿瘤免疫治疗提供新的理解。

Abstract:

In recent years, the landscape of cancer treatment has been transformed by the advent of immunotherapy. However, the effectiveness of single-agent immunotherapy remains relatively limited. Combining immunotherapy with chemotherapy or targeted therapy has emerged as a strategy to achieve a synergistic antitumor effect by modulating the tumor microenvironment. Amino acid metabolism, particularly taurine metabolism, holds the promise of enhancing the efficacy of immunotherapy through metabolic reprogramming of the microenvironment. This article specifically delves into the potential mechanisms through which taurine regulates the tumor microenvironment and tumor cell metabolism, with the aim of offering novel insights into tumor immunotherapy.