间充质干细胞来源的外泌体治疗器官纤维化的研究进展

Research progress of mesenchymal stem cells-derived exosomes in the treatment of organ fibrosis

摘要:

器官纤维化是组织损伤后过度修复的结果，与器官衰竭和高死亡率有关，因而寻找有效的治疗纤维化的方法具有重要价值。近年来研究发现间充质干细胞来源的外泌体具有体积小、免疫原性低、无致瘤作用等优势，在抗纤维化方面显示出良好的应用前景。该文综述了间充质干细胞来源的外泌体治疗各种器官纤维化的机制及相关研究进展。

Abstract:

Organ fibrosis is the result of overrepair after tissue damage, and is associated with organ failure and high mortality. Therefore, it is of great value to find effective treatment methods for fibrosis. In recent years, it has been found that mesenchymal stem cells-derived exosomes have the advantages of smaller size, low immunogenicity and no tumorigenic effect, showing a good application prospect in anti-fibrosis. This article reviews the mechanism of treating various organ fibrosis with mesenchymal stem cells-derived exosomes.