ASC自身抗体及总胆固醇与阿尔茨海默病的相关性研究

Association of plasma naturally occurring antibodies against ASC and total cholesterol with Alzheimer's disease

摘要:

目的 探讨凋亡相关斑点样蛋白自身抗体（NAbs-ASC）及总胆固醇（TC）与阿尔茨海默病（AD）的相关性。方法 选取2022年10月—12月陆军军医大学大坪医院神经内科门诊38例AD患者及健康管理科38例为对照组。比较两组血浆NAbs-ASC及总胆固醇水平，分析NAbs-ASC及TC与AD的相关性。结果 AD组血浆的NAbs-ASC水平低于对照组（P <0.05），总胆固醇水平高于对照组（P <0.05）。Spearman相关性分析显示，NAbs-ASC水平与总胆固醇水平呈负相关（r_s =-0.290，P <0.05），认知功能水平与总胆固醇水平呈负相关（r_s =-0.380，P <0.05），而与血浆NAbs-ASC水平呈正相关（r_s =0.550，P <0.05）。多因素Logistic回归分析结果显示，总胆固醇升高为AD的危险因素［O^R =3.004（95% CI：1.075，8.396）］，NAbs-ASC升高为AD的保护因素［O^R =0.998（95% CI：0.997，0.999）］。结论 NAbs-ASC降低、总胆固醇升高与AD有相关性，并与认知功能水平下降有关。

Abstract:

Objective To investigate the correlation between apoptosis-associated speck-like protein containing a CARD autoantibodies (NAbs-ASC) and total cholesterol (TC) levels with Alzheimer's disease (AD).Methods A total of 38 AD patients from the Neurology Department of Daping Hospital, Army Medical University, between October and December 2022, were selected, along with 38 healthy individuals from the Health Management Department as the control group. Plasma levels of NAbs-ASC and TC were compared between the two groups, and the correlation between NAbs-ASC, TC, and AD was analyzed.Results The plasma levels of NAbs-ASC in the AD group were lower than those in the control group (P < 0.05), while the TC levels were higher (P < 0.05). Spearman correlation analysis showed a negative correlation between NAbs-ASC levels and TC levels (r_s = -0.290, P < 0.05), a negative correlation between cognitive function levels and TC levels (r_s = -0.380, P < 0.05), and a positive correlation between plasma NAbs-ASC levels and cognitive function levels (r_s = 0.550, P < 0.05). Multifactorial logistic regression analysis showed that elevated TC was a risk factor for AD [O^R = 3.004 (95% CI: 1.075, 8.396)], while elevated NAbs-ASC was a protective factor for AD [O^R = 0.998 (95% CI: 0.997, 0.999)].Conclusions The decrease in NAbs-ASC and the increase in TC are correlated with AD and are associated with the decline in cognitive function.