血清趋化素水平与慢性心力衰竭患者左室重构的相关性研究

Association between serum chemerin expression and left ventricular remodeling in patients with chronic heart failure

摘要:

目的 通过测定慢性心力衰竭（以下简称心衰）患者血清趋化素表达水平，探讨其与心衰及心 室重构的相关性。方法 纳入60 例慢性心衰患者，心功能Ⅱ级16 例，心功能Ⅲ级26 例，心功能Ⅳ级18 例， 应用超声心动图测定射血分数、左房内径、左室舒张末期内径、室间隔厚度、左室后壁厚度，计算左室质 量和左室质量指数。另设同期住院的心功能正常患者60 例为对照组，测定所有患者的血清趋化素表达水平。 结果 心衰组血清趋化素表达水平高于对照组，且随心衰程度的加重而升高（P <0.05），血清趋化素表达水平 与左室质量指数呈正相关（r =0.401，P =0.022），与左室射血分数呈负相关（r =-0.455，P =0.021）。结论 血 清趋化素作为一个新的心衰标志物，可以评估心衰的程度、判断心衰的预后，且趋化素与左室重构相关，对其 进行干预可能有助于心衰的治疗。

关键词:血清趋化素;心力衰竭;心室重构;心脏功能

Abstract:

Objective To determine the level of serum chemerin and investigate the correlation between chemerin and ventricular remodeling in patients with chronic heart failure (CHF). Methods Sixty patients with chronic heart failure were selected as CHF group in this study (16 cases with cardiac function grade II, 26 cases with grade III, and 18 cases with grade IV). Menwhile 60 patients with normal cardiac function were enrolled as control group. Ultrasound echocardiography was performed to measure left ventricular ejection fraction (LVEF), left atrial diameter (LAD), left ventricular end diastolic diameter (LVEDD), interventricular septal thickness (IVST) and left ventricular posterior wall thickness (LVPWT), and then left ventricular mass (LVM) and left ventricular mass index (LVMI) were calculated. The serum level of chemerin was measured in all the selected subjects. Results The serum level of chemerin in the patients of the CHF group was significantly higher than that in the control group and increased with the exacerbation of heart failure (P < 0.05). And the serum chemerin level was positively correlated with LVMI (r = 0.401, P = 0.022), but was negatively correlated with LVEF (r = -0.455, P = 0.021). Conclusions Serum chemerin is related to the left ventricular remodeling and can be identified as a new marker for heart failure. It may be used to assess the extent of heart failure and evaluate the prognosis of heart failure.

Key words:chemerin; serum; heart failure; left ventricular remodeling; cardiac function