Abstract:Objective To evaluate the adhesion of self-etching adhesive system to Tetracycline dentin. Methods From June 2004 to April 2016, 56 teeth with self-etching Tetracycline dentin and 56 teeth with total-etching Tetracycline dentin were selected according to the random number table method, and according to the ratio of 1: 1 the self-etching and total-etching healthy teeth were selected with 56 in each group. The adhesive strength and fracture patterns of the four groups were compared. Results Before and after thermal cycling, the microtensile bonding strength of the self-etching Tetracycline dentin group, the self-etching healthy dentin group and the total-etching healthy dentin group was significantly higher than that of the total-etching Tetracycline dentin group (P < 0.05). Before and after thermal cycling, the shear bonding strength of the self-etching healthy dentin group was significantly higher than that of the other three groups, the shear bonding strength of the self-etching Tetracycline dentin group was statistically higher than that of the total-etching dentin Tetracycline group and the total-etching healthy dentin group (P < 0.05). The microtensile bonding strength and shear bonding strength of the four groups were decreased after hot and cold cycles. The microtensile fracture mode of the four groups was mainly mixed fracture, the proportion was 85.71%, 87.50%, 85.71%, and 75.00% respectively. Conclusions The adhesive effect of self-etching adhesive system is better, and the adhesive strength to Tetracycline dentin is higher than that of alletching adhesive, and the adhesive strength decreases after thermal cycling treatment.