含胰岛素心肌保护液的心肌保护作用

Myocardial protective effect of insulin-containing cardioplegia

摘要:

目的 研究含胰岛素心肌保护液对心内直视手术的心肌保护效果。方法 体外循环心脏手术 患者68 例，随机分为A、B 两组，每组34 例，A 组采用含胰岛素心肌保护液进行灌注，B 组采用含血心肌 保护液灌注。观察两组患者自动复跳率、血管活性药物的使用情况、心肌酶的变化和心肌超微结果的变化。 结果 A 组患者自动复跳率较高，心脏手术过程中停跳液只需灌注1 次。两组手术前后心肌酶的变化和心肌 细胞超微结构无差异。结论 含胰岛素心肌保护液配制简单，心脏手术过程中灌注次数较少，心肌保护效果 较好，缩短了手术时间。

Abstract:

Objective To study the cardioprotective effect of cardioplegia containing insulin in open-heart surgery. Methods Sixty-eight patients undergoing open-heart surgery were randomly divided into group A and group B, each group had 34 patients. The patients in the group A were perfused with cardioplegia containing insulin, while those in the group B were perfused with cardioplegia containing blood. Then auto-rebeat rate of heart, use of vasoactive agents, changes of myocardial enzymes and myocardial ultrastructures were observed. Results The autorebeat rate of heart in the patients of the group A was higher, and cardioplegia was only needed to be perfused once in the heart surgery. There were no obvious differences in the changes of myocardial enzymes or the myocardial ultrastructures between the two groups. Conclusions Cardioplegia containing insulin has the advantages of simple preparation, fewer times of perfusion in surgery, better protective effect and shorter operative time.