血清BDNF 与MG 对原发性高血压患者认知功能水平的影响

Effect of serum BDNF and MG on cognitive function in patients with primary hypertension

摘要:

目的 探讨血清脑源性神经营养因子（BDNF）与甲基乙二醛(MG) 对原发性高血压患者认知功 能水平的影响。方法 选取2013 年7 月-2017 年7 月在遵义第一人民医院市政府门诊部住院治疗或门诊就诊 的高血压患者208 例为研究组，同时期在该院进行体检且不合并高血压者208 例为对照组，比较两组的一般 资料和临床资料；比较两组血清BDNF 和MG 含量；比较两组认知功能；确定血清BDNF 与MG 与原发性 高血压患者认知功能的关系。结果 研究组BDNF 含量低于对照组（P <0.05），研究组MG 含量高于对照组 （P <0.05）；研究组即刻记忆（IM）、延时记忆（DLM）、注意力（ATT）、视觉广度（LF）、标准化测验总分（STS） 评分均低于对照组（P <0.05）；研究组血清BDNF 与IM、DLM、ATT、LF 及STS 评分呈正相关（P <0.05）； 研究组血清MG 与IM、DLM、ATT 及STS 评分呈负相关（P <0.05）。结论 高血压患者的认知功能与血清 BDNF 和MG 存在相关性，血清BDNF 降低和MG 升高均可提示高血压患者的认知功能降低，为治疗高血压 认知功能障碍提供新的途径。

Abstract:

Objective To investigate the effect of serum BDNF and MG on cognitive function in patients with primary hypertension. Methods A total of 208 patients with primary hypertension admitted from July 2013 to July 2017 in our hospital were involved in this study. Another 208 cases of healthy volunteers without hypertension were selected as control group. Cognitive function was analyzed with the scores of IM, DLM, ATT, LF and STS. Association of serum BDNF and MG with cognitive function was determined. Results Concentration of BDNF was decreased while that of MG was increased significantly in study group when compared with the control group (P < 0.05). The scores of IM, DLM, ATT, LF and STS in the study group decreased compared with control group (P < 0.05). Positive correlation between serum BDNF and cognitive function including score of IM, DLM, ATT, LF, and STS scores were founded in study group (P < 0.05), while MG was negatively correlated with IM, DLM, ATT and STS scores in patients with hypertension (P < 0.05). Conclusion The cognitive function of hypertensive patients is positively correlated with circulating BDNF while is negatively correlated with MG, which may provide a new approach for the treatment of cognitive dysfunction in hypertensive patients.