Abstract:Objective To explore the clinical value of breast reconstruction with prosthesis covered by a retrograde myofascial fascia combined with pectoralis major myocutaneous flap at the first stage of breast resectionin patients with early breast cancer. Methods The clinical date of 23 cases with early breast cancer were collected from June 2015 to Feb. 2017 in Hunan People's Hospital. The operation characteristics and surgical indications were analyzed. Results The one-stage breast reconstruction was performed in 23 cases with early breast cancer by modified mastectomy. Among them, 1 case had the local breast skin becomingpurple, and gradually returned by changing of dressing and symptomatic treatment; 1 case of small cell neuroendocrine carcinoma of the breast died of liver metastases in 6 months after surgery. Breast reconstruction was of good shape, natural appearance, good handle, little scar and high satisfaction rate. Conclusions Retaining pectoralis major fascia with one-stage prosthesis is relatively safe and simple, and is of satisfactory cosmetic results and few complications for breast reconstruction. which is suitable for breast reconstruction of early breast cancer.