锌指蛋白217 在非小细胞肺癌组织中的表达及其临床意义

Expression of zinc finger protein 217 in non-small cell lung cancer and clinical significance

摘要:

目的 检测锌指蛋白217（ZNF217）在非小细胞细胞癌中的表达，探讨其与非小细胞肺癌患者 临床病理特征的关系，并分析其与非小细胞肺癌患者生存及预后的关系。方法 利用实时荧光定量聚合酶链 反应（qRT-PCR）检测非小细胞肺癌组织及对应癌旁组织中ZNF217 的表达水平，并利用统计学软件分析 ZNF217 的临床相关性。结果 ZNF217 在非小细胞肺癌组织中的表达水平高于癌旁组织。非小细胞肺癌组 织中ZNF217 的表达水平与非小细胞肺癌患者TNM 分期及淋巴结转移情况呈正相关，与其他临床病理特征 无相关。Kaplan-Meier 生存曲线结果发现ZNF217 表达与患者术后5 年总体生存率及无进展生存率均呈负相 关。Cox 风险比例模型结果发现ZNF217 可作为判断非小细胞肺癌预后独立的预测指标。结论 ZNF217 在 非小细胞肺癌组织中表达升高，并可作为判断非小细胞肺癌患者生存及预后的指标。

Abstract:

Objective To explore the expression of zinc finger protein 217 (ZNF217) in tissues of non-small cell lung cancer (NSCLC), investigate the relationships between ZNF217 expression and clinicopathological features of NSCLC patients, and analyze the associations of ZNF217 with survival time after surgery and prognosis of NSCLC patients. Methods Expression of ZNF217 was analyzed by qRT-PCR in 77 NSCLC patients. SPSS 22.0 software was used to analyze the clinical relevance of ZNF217 in NSCLC. Results qRT-PCR revealed that the mRNA level of ZNF217 in the NSCLC tissues was significantly higher than that in the adjacent tissues. Chi-square analysis revealed that ZNF217 level was positively associated with TNM stage and lymph node metastasis of NSCLC patients. Kaplan-Meier curves revealed that ZNF217 level was negatively associated with postoperative 5-year overall survival rate and progression-free survival rate in the NSCLC patients after surgery. Cox proportional hazards risk analysis revealed that ZNF217 was an independent prognostic factor for NSCLC. Conclusions ZNF217 expression is upregulated in NSCLC, and could be used as a survival and prognosis predictor for NSCLC patients.