血液透析患者便秘情况及其相关因素分析

Retrospective analysis of constipation and risk factors in chronic hemodialysis patients

摘要:

目的 对慢性肾脏病（CKD）维持血液透析（HD）患者便秘的发生情况及其相关因素进行调查。 方法 根据Rome Ⅲ诊断标准制作调查表，选取2016 年3 月该院行HD 患者进行问卷调查，了解其便秘的发生 情况，并探讨其相关因素。结果 共调查206 例HD 患者，193 例应答，应答率为93.7% ；便秘发生率为34.2%。 单因素分析结果显示，HD 充分性（Kt/V）、血清硫酸吲哚酚（IS）水平、每日蔬菜摄入量、进食蔬菜、水果 及运动习惯与HD 患者便秘相关。逐步多因素Logistic 回归分析提示，IS 水平[O^R=1.051（95%CI ：1.009， 1.095）] 和Kt/V[O^R=0.264（95%CI ：0.074，0.945）] 是HD 患者发生便秘的主要影响因素。结论 HD 患者 有较高的便秘发生率。IS 蓄积是HD 患者发生便秘的危险因素，而较高的Kt/V 则是保护因素。

Abstract:

Objective To investigate the prevalence of constipation and risk factors in hemodialysis patients. Methods Based on Rome III, questionnaire about bowl evacuation habi twere sent out to patients on chronic hemodialysis in March 2016. Results Totally 193 out of 206 patients were inquired and responded (93.7%). The incidence of constipation was 34.2%. Single factor analysis showed that dialysis adequacy (Kt/V), serum indoxyl sulfate (IS), daily intake of vegetables, frequency of eating vegetables and fruits and frequency of exercises affected the development of constipation. Multivariate logistic regression analysis suggested that serum IS level and Kt/V were independent factors of constipation. Conclusions High prevalence of constipation in chronic hemodialysis patients exists and increased level of IS is risk factor while higher level of Kt/V is protective factor for conatipation .