高危HPV 阴性宫颈癌患者的临床病理特征研究

Clinicopathological characteristics of high-risk human papillomavirus negative cervical cancer

摘要:

目的 探究高危人乳头瘤病毒（HPV）阴性宫颈癌（CC）患者的临床病理特征。方法 回顾性分析 2013 年1 月-2017 年1 月湖北省肿瘤医院收治1 123 例宫颈癌患者的临床资料，所有患者均由HPV-DNA 检测 和薄层液基细胞学技术检测为CC，高危HPV 的13 种型别检测为任何一型即可诊断为高危型HPV 阳性，反之 为阴性。分析患者的年龄构成、临床分期及病理类型，比较HPV-DNA 检测和薄层液基细胞学技术检测的筛 查价值。结果 两组高危型HPV 患者的年龄构成比较，差异无统计学意义（P >0.05）；高危型HPV 阴性组腺 癌比例高于高危型HPV 阳性组（P <0.05），而高危型HPV 阴性组Ⅱ b+ Ⅲ - Ⅳ期比例高于高危型HPV 阳性 组（P <0.05）；HPV-DNA 检测对高危HPV 阴性宫颈癌患者的诊断敏感性和阴性预测值较高。结论 HPVDNA 检测能较好诊断高危型HPV 阴性宫颈癌，患者多发于36 ～ 50 岁，且以腺癌为主。

Abstract:

Objective To investigate the clinicopathological features of high-risk human papillomavirus (HPV) negative cervical cancer. Methods Retrospective analysis of the clinical data of 1123 cases of cervical cancer in our hospital from January 2013 to January 2017 was made, all the patients were diagnosed with cervical cancer by HPV-DNA test and thin-layer liquid-based cytology. There are 13 types of high-risk HPV positivity.Age, clinical stage and pathological type of the patients were analyzed and the screening value of HPV-DNA test and TLC-based cytology test were compared. Results There was no significant difference in the age of high-risk HPV-positive group and high-risk HPV negative group (P > 0.05). The proportion of adenocarcinoma in high-risk HPV-negative group was higher than that in high-risk HPV group (P < 0.05). Diagnostic sensitivity and negative predictive value were higher in high-risk HPV-negative cervical cancer with HPV-DNA detection. Conclusion HPV-DNA can be used for diagnosis of high-risk HPV negative cervical cancer; onset age of the cancer is from 36 years old to 50 years old and adenocarcinoma dominates.