唐山地震截瘫患者血清25- 羟维生素D及钙磷水平分析

Analysis of serum 25 (OH) D3, calcium and phosphorus for paraplegia patients

摘要:

目的 检测唐山地震截瘫患者血清25- 羟维生素D[ 血清25- 羟维生素D] 及钙磷水平，为截瘫患者骨质 疏松症预防和治疗提供依据。方法 采集110 例截瘫患者静脉血，用酶法、邻甲酚酞络合铜法及钼酸铵法分别测定 25（OH）D3、钙及磷水平，并进行3 者之间的相关性分析。结果 截瘫组血清25（OH）D3（20.61±9.21）nmol/L、 钙（2.27±0.11）mmol/L 及钙磷乘积（33.93±5.12）mg2/dl2 均低于对照组，差异有统计学意义（均P <0.05）。 血清磷浓度（1.22±0.16）mmol/L 有升高趋势，差异无统计学意义。按性别分层，除血清磷外，血清25（OH） D3、钙浓度及钙磷乘积比较，差异无统计学意义（P >0.05）。血清中25（OH）D3、钙、磷及钙磷乘积无相关性。 结论 唐山地震截瘫患者血清25（OH）D3、钙水平降低，检测其浓度对骨质疏松的防治有辅助作用。

Abstract:

Objective To detect the levels of serum 25 (OH) D3, calcium (Ca) and phosphorus (P) to provide evidence for prevention and treatment of osteoporosis in paraplegia patients. Methods A total of 110 paraplegia patients′venous blood were collected; enzymic method, o-cresolphthalein complex copper and ammonium molybdate method were used to determine serum 25 (OH) D3, Ca and P; the correlation analysis among serum 25 (OH) D3, Ca and P were carried out. Results Levels of 25 (OH) D3 (20.61 ± 9.21 nmol/L), Ca (2.27 ± 0.11 mmol/L) and calcium-phosphorous product (33.93 ± 5.12 mg2/dl2) of the paraplegia patients Were notable lower than control group (P < 0.05). Concentration of P (1.22 ± 0.16 mmol/L) increased, but there was no statistical significance (P > 0.05). Stratified by gender, the levels of serum 25 (OH) D3, Ca and calcium-phosphorous product were not statistically significant except for serum P. There were no notable correlations among serum 25 (OH) D3, Ca and P. Conclusions Levels of serum 25 (OH) D3 and Ca of Tangshan paraplegia patients decrease and detecting the levels of serum 25 (OH) D3 and Ca can provide evidence for prevention and treatment of osteoporosis in paraplegia patients.