急性脑梗死患者血清中CyPA、Lp-PLA2 含量 与动脉粥样硬化、神经损伤的相关性

Correlations of serum CyPA and Lp-PLA2 levels with atherosclerosis and nerve injury in patients with acute cerebral infarction

摘要:

目的 分析急性脑梗死患者血清中亲环素A（CyPA）、脂蛋白相关磷脂酶A2（Lp-PLA2）含量与 动脉粥样硬化、神经损伤的相关性。方法 2014 年5 月-2016 年5 月在郑州人民医院接受住院治疗的急性脑 梗死患者49 例作为观察组，同期在该院进行体检的健康人49 例作为对照组。入院后即刻，检测两组患者的血清 CyPA、Lp-PLA2、淀粉蛋白A（SAA）、胰岛素样生长因子1（IGF-1）、神经元特异性烯醇化酶（NSE）及脑 源性神经营养因子（BDNF）含量，采用数字彩色多普勒超声仪测定颈动脉内膜中层厚度（CIMT）和斑块最 大面积，计算颈动脉斑块的Crouse 积分。结果 入院后即刻，观察组患者的血清CyPA、Lp-PLA2 含量高于 对照组（P <0.05）；观察组患者的动脉粥样硬化指标CIMT、斑块最大面积、Crouse 积分高于对照组（P <0.05）； 观察组患者的血清神经损伤指标SAA、NSE 含量高于对照组，观察组患者的IGF-1、BDNF 含量低于对照组（P < 0.05）；经Pearson 检验发现，急性脑梗死患者的血清CyPA、Lp-PLA2 含量与动脉粥样硬化、神经损伤指标呈直 接相关关系。结论 急性脑梗死患者血清CyPA、Lp-PLA2 含量上升，与动脉粥样硬化、神经损伤等病情直接相关。

Abstract:

Objective To study the relationships of serum cyclophilin A (CyPA), lipoprotein-associated phospholipase A2 (Lp-PLA2) levels with atherosclerosis and nerve injury in acute cerebral infarction patients. Methods Forty-nine cases of acute cerebral infarction patients in our hospital between May 2014 and May 2016 were taken as observation group and other forty-nine healthy persons who underwent physical examination in our hospital at the same time were taken as control group. Immediately after admission, serum levels of CyPA, Lp-PLA2, amyloid A (SAA), insulin-like growth factor-1 (IGF-1), neuron-specific enolase (NSE) and brain-derived neurotrophic factor (BDNF) were tested in the two groups. Carotid artery intima-media thickness (CIMT) and maximum plaque size were detected by digital color Doppler ultrasonic diagnostic apparatus, and Crouse integral of the carotid plaques was calculated. Results Immediately after admission, serum content of CyPA and Lp-PLA2 in the observation group was significantly higher than that in the control group (P < 0.05); atherosclerotic plaque indexes CIMT, maximum plaque area and Crouse score in the observation group were significantly higher than those in the control group (P < 0.05); serum nerve injury indexes SAA and NSE were higher in the observation group than in the control group, IGF- 1 and BDNF levels were lower in the observation group than in the control group (P < 0.05). Pearson test showed that serum CyPA and Lp-PLA2 levels had direct correlations with atherosclerosis and nerve injury indexes in the patients with acute cerebral infarction patients. Conclusions Serum content of CyPA and Lp-PLA2 increases in acute cerebral infarction patients, which is directly related to the severity of atherosclerosis and nerve injury.