自身免疫性甲状腺炎与乳腺癌关系的Meta 分析

A Meta analysis on relationship between autoimmune thyroiditis and breast cancer

摘要:

目的 通过收集整理相关数据明确自身免疫性甲状腺炎与乳腺癌关系。方法 通过计算机检索 PubMed、Cochrane 图书馆、Embase、谷歌学术等英文数据库，检索时间截至2017 年5 月15 日有关自身免疫性 甲状腺炎与乳腺癌相关的文献，提取相关数据并用Stata 12.0 软件进行统计分析。结果 共纳入9 篇横断面研究（累 计样本量1 325 例），经Meta 分析，显示甲状腺过氧化物酶抗体（TPOAb）、甲状腺球蛋白抗体（TGAb）对 乳腺癌的作用合并效应Ol ^ R 值分别为2.66（95%CI ：1.93，3.68）、2.30（95%CI ：1.67，3.18），差异有统计学意义。 结论 乳腺癌患者中血清TPOAb 和TGAb 高于健康者。

Abstract:

Objective To summarize and analyze the available data on relationship between autoimmune thyroiditis and breast cancer. Methods The relevant studies were collected by searching databases of PubMed, Cochrane Library, Embase and Google Scholar up to May 15, 2017. The relevant data were extracted and the statistical analyses were conducted by Stata 12.0 software. Results Of 3,059 identified studies, 9 were eligible and were included in our analyses (including 1,325 participants). There was a significant evidence of an increased risk of breast cancer in the patients with autoimmune thyroiditis [for thyroid peroxidase antibody, O^R = 2.66, 95% CI (1.93, 3.68); for thyroglobulin antibody, O^R = 2.30, 95% CI (1.67, 3.18)]. Conclusions The present results indicated that the serum levels of thyroid peroxidase antibody and thyroglobulin antibody are significantly higher in patients with breast cancer than in healthy controls.