CA Ⅸ在乳腺癌组织中的表达及其临床意义

Expression of CAIX in breast cancer and its clinical significance

摘要:

目的 探讨碳酸酐酶Ⅸ（CA Ⅸ）蛋白在乳腺癌组织中的表达差异，以及与乳腺癌患者临床病理 特征的关系。方法 选取2013 年6 月-2016 年1 月郑州人民医院病理科收集的乳腺癌组织标本120 例，其中 80 例为标准的乳腺良性肿瘤标本。采用免疫组织化学法检测两组CA Ⅸ蛋白表达水平，并分析其与临床病理 特征的关系。结果 乳腺癌组织的CA Ⅸ蛋白阳性表达率为61.67%，高于乳腺良性肿瘤的18.75%（P <0.05）； 乳腺癌组织CA Ⅸ蛋白阳性表达与患者的TNM 分期、分化程度、Ki-67 蛋白表达有相关性（P <0.05），与 患者年龄、淋巴结转移、病灶直径、雌激素受体、孕激素受体、Cerb-2 蛋白表达无相关性（P >0.05）。 结论 CA Ⅸ蛋白在乳腺癌组织中高表达，并且与患者的TNM 分期、分化程度、Ki-67 蛋白表达有相关性。

Abstract:

Objective To investigate the protein expression of carbonic anhydrase IX (CAIX) in breast carcinoma tissues and its relationship with the clinicopathological characteristics of the patients with breast cancer. Methods From June 2013 to January 2016, 120 breast cancer specimens and 80 specimens of benign breast tumor were collected from the Department of Pathology in our hospital. The expression of CAIX protein was detected by immunohistochemistry and the relationships between the expression of CAIX protein and clinicopathological features were also discussed. Results The positive expression rate of CAIX protein in the breast cancer tissues (61.67%) was significantly higher than that in the benign breast tumor (18.75%), the difference was statistically significant (P < 0.05). The positive expression of CAIX protein in the breast cancer tissues was correlated with TNM stage, differentiation degree and Ki-67 protein expression (P < 0.05), but not correlated to ER, PR, Cerb-2 protein expression, age, lymphatic metastasis or lesion diameter (P > 0.05). Conclusions CAIX protein is highly expressed in breast cancer tissues, and the expression is correlated with TNM stage, degree of differentiation and Ki-67 protein expression.