骨髓微环境信号通路介导的白血病 耐药机制研究进展

Research progress on mechanism of drug resistance in leukemia mediated by bone marrow microenvironment signaling pathway

摘要:

白血病是造血组织异常增生的恶性肿瘤性疾病，虽然对其发病机制的研究越来越深入，但其耐药 和复发仍是世界医学的难题。目前已知骨髓微环境对白血病耐药起着至关重要的作用。骨髓微环境可通过多 条不同的信号通路，促使白血病细胞存活、增殖及抗细胞凋亡等，进而介导白血病的耐药性。

Abstract:

Leukemia is a malignant tumor of hematopoietic dysplasia, although the researches on its pathogenesis are getting deeper and deeper, the drug resistance and relapse are still difficult problems in the world of medicine. It is known that bone marrow microenvironment plays an important role in drug resistance of leukemia. Bone marrow microenvironment can promote the survival, proliferation and anti-apoptosis of leukemic cells through multiple signaling pathways, and mediate the drug resistance of leukemia. In this paper, we review the mechanism of drug resistance mediated by the major signaling pathways in the bone marrow microenvironment.