Th17、IL-17 在长程持续性心房颤动中的作用机制

Roles of Th17 and IL-17 in persistent atrial fibrillation

摘要:

目的 探讨外周血中辅助性T 细胞17（Th17）及其细胞因子在长程持续性心房颤动（以下简称 房颤）中的作用机制。方法 回顾性收集2017 年1 月-2017 年12 月该院收治的长程持续性房颤患者的临床 资料，将该50 例作为观察组，选取同期健康成人50 例作为对照组。观察两组外周血中Th17 及其细胞因子表 达水平，并进一步分析长程持续性房颤患者Th17、白介素-17（IL-17）与临床特征的相关性。结果 与对 照组比较，观察组Th17、IL-17 升高（P <0.05）。合并高血压患者的Th17 水平高于未合并高血压患者（P <0.05）； 合并高血压或糖尿病房颤患者的IL-17 水平高于未合并患者（P <0.05）。长程持续性房颤患者Th17、IL-17 与左室内射血分数呈负相关（r =-0.212 和-0.209，P =0.021 和0.028）。结论 长程持续性房颤患者外周血中 Th17、IL-17 升高，与高血压、糖尿病和心功能不全有关。

Abstract:

Objective To investigate the mechanism of T helper cell 17 (Th17) and its cytokines of peripheral blood in long-standing persistent atrial fibrillation. Methods From January to December 2017, 50 patients with long-standing persistent atrial fibrillation in our hospital were selected as an observation group, and 50 healthy adults were served as a control group. The expression levels of Th17 and its cytokines were observed in both groups, and the correlations of Th17 and interleukin -17 (IL-17) with clinical characteristics of the patients were further analyzed. Results Compared with the control group, the Th17 and IL-17 increased in the observation group (P < 0.05). Th17 in the patients with long-standing persistent atrial fibrillation complicated with hypertension was higher than that of the patients without hypertension (P < 0.05). IL-17 in the patients with long-standing persistent atrial fibrillation complicated with hypertension or diabetes was higher than that of the patients without hypertension or diabetes (P < 0.05). Th17 and IL-17 in the patients with long-standing persistent atrial fibrillation were negatively correlated with left ventricular ejection fraction (r = -0.212 and -0.209, P = 0.021 and 0.028). Conclusions The increase of Th17 and IL-17 in the peripheral blood of the patients with long-standing persistent atrial fibrillation is related to hypertension, diabetes and cardiac insufficiency.