桥本甲状腺炎自身抗体与甲状腺 功能的相关性分析

Correlations between thyroid autoantibodies and thyroid function in patients with newly-diagnosed Hashimoto’s thyroiditis

摘要:

目的 探讨初诊桥本甲状腺炎（HT）患者的抗甲状腺微粒体抗体（TmAb）和抗甲状腺球蛋白 抗体（TgAb）与甲状腺功能的相关性。方法 收集初诊甲状腺肿患者313 例，其中HT 患者132 例，非HT 患者181 例，检测血清TmAb、TgAb、TSH、FT3、FT4、TT3、TT4 及B 超测定甲状腺大小，分析抗体与甲 状腺功能的相关性。结果 HT 患者年龄低于非HT 患者，TSH 高于非HT 患者（P <0.05）；HT 女性患者的 TSH、TmAb 及TgAb 与男性患者无差异（P >0.05），但FT3、FT4、TT3 及TT4 低于男性（P <0.05），非HT 女性患者年龄、FT3 及FT4 低于男性患者（P <0.05）；HT 患者中TmAb 与TSH 呈正相关（P <0.05），与FT4 呈负相关（P <0.05），TgAb 与FT3、FT4 及TT4 呈负相关（P <0.05）。结论 初诊HT 患者自身抗体和性别与 甲状腺功能存在密切关系，但抗体在甲状腺损伤过程中呈现不同作用特点。

关键词:桥本甲状腺炎;甲状腺微粒体抗体;甲状腺球蛋白抗体;甲状腺功能

Abstract:

Objective To explore the relationships between TmAb, TgAb and thyroid function in the patients with newly-diagnosed Hashimoto’s thyroiditis (HT). Mehtods The cases of goiter patients (n = 313) were collected, which included HT patients (n = 132) and non-HT patients (n = 181). Serum TmAb, TgAb, TSH, FT3, FT4, TT3 and TT4 of each patient were detected, and the sizes of thyroid gland were recorded through ultrosonography. The correlations of TmAb and TgAb with thyroid function were analyzed. Results Compared with the non-HT group, the patients’ age was younger, and the TSH level was higher in the HT group (P < 0.05). The levels of TSH, TmAb and TgAb in the female HT patients were comparable to those in the male HT patients. However, the levels of FT3, FT4, TT3 and TT4 in the female HT patients were lower than those in the male HT patients (P < 0.05). The levels of FT3 and FT4 in the female non-HT patients were lower than those in the male non-HT patients, and their age was younger than that in the male non-HT patients (P < 0.05). Pearson correlation analysis showed that TmAb was positively correlated with TSH, and negatively correlated with FT4 in the patients with HT (P < 0.05); TgAb was negatively correlated with FT3, FT4 and TT4 (P < 0.05). Conclusions In newly-diagnosed HT patients, TmAb, TgAb and gender are closely correlated with the function of thyroid and these two antibodies indicate different patterns in thyroid damage.

Key words:Hashimoto’s thyroiditis ; TmAb ; TgAb ; thyroid function