MicroRNA-1469 低表达与食管鳞状细胞癌 临床病理特征及预后的关系

Relationships of low expression of miR-1469 with progression and clinical outcomes of esophageal squamous cell carcinoma

摘要:

目的 探讨microRNA-1469（miR-1469）低表达与食管鳞状细胞癌临床病理特征及预后的关系。 方法 通过实时荧光定量聚合酶链反应（qRT-PCR）检测食管鳞癌术后肿瘤组织中miR-1469 的表达情况， χ2 检验分析不同临床病理特征患者miR-1469 的表达水平，Kaplan-Meier 方法绘制生存曲线，Log-rank 检验比 较不同组别生存曲线的差异。结果 miR-1469 的表达水平与浸润深度、淋巴结转移及病理分期差异有统计学 意义（P <0.05）。生存分析提示miR-1469 低表达的患者其无瘤生存率（17.9% vs 42.8%，P =0.004）及术后5 年 总生存率（29.3% vs 47.1%，P =0.027）均降低。在N1-3 的患者中，低表达miR-1469 组的5 年无瘤生存率低于高 表达组（7.3% vs 31.5%，P =0.043）。结论 通过检测miR-1469 的表达情况，可以预测食管癌患者疾病进程及术 后临床预后。

Abstract:

Objective To explore the relationships of low expression of miR-1469 with progression and unfavorable post-surgical clinical outcomes in patients with esophageal squamous cell carcinoma. Methods The expression of miR-1469 was detected by qRT-PCR in the patients who successfully underwent esophagectomy for esophageal squamous cell carcinoma. Then χ2 test, Kaplan-Meier method, and Log-rank test were performed. Results There were statistical differences in cancer invasion depth, lymph node metastasis and pathologic stage between the miR-1469 low-expression and high-expression groups (P < 0.05). The patients with miR-1469 low expression had significantly lower disease-free survival rate (17.9% vs. 42.8%, P = 0.004) and post-operative 5-year overall survival rate (29.31% vs. 47.1%, P = 0.027). miR-1469 low expression significantly predicted unfavorable 5-year disease-free survival rate among the patients with N1-3 (7.3% vs 31.5%, P = 0.043). Conclusions The expression of miR-1469 could predict disease progression and post-surgical clinical outcomes for patients with esophageal squamous cell carcinoma.