医用臭氧配合羟考酮缓释剂治疗中重度癌痛的 临床观察

Clinical efficacy of medical ozone combined with slow-release oxycodone hydrochloride in treatment of moderate to severe cancer pain

摘要:

目的 观察医用臭氧配合羟考酮缓释剂治疗中重度癌痛时，对患者疼痛缓解、精神状态、安全性及 生活质量的影响。方法 选取癌痛患者80 例，随机分为联合组和羟考酮组，每组40 例，联合组给予羟考酮缓释 剂联合医用臭氧治疗，羟考酮组单纯给予羟考酮缓释剂治疗。记录治疗前、治疗后2 周、出院后1 个月的疼痛 评分、抑郁评分、生活质量、用药量及不良反应情况。结果 治疗后两组患者疼痛评分比较差异无统计学意义， 均控制良好。治疗后2 周、出院后1 个月两组羟考酮缓释剂及吗啡用药量比较，差异有统计学意义（P <0.05）， 联合组均小于羟考酮组；治疗后2 周、出院后1 个月联合组患者生活质量、抑郁情况改善更明显；两组患者 均无严重并发症发生，两组恶心呕吐、嗜睡、瘙痒的不良反应发生率比较，差异有统计学意义（P <0.05），羟 考酮组高于联合组。结论 医用臭氧配合羟考酮缓释剂治疗中重度癌痛，可改善患者情绪及生活质量，减少阿 片类药物用量并且无明显并发症，建议临床应用。

Abstract:

Objective To observe the effect of medical ozone combined with slow-release oxycodone hydrochloride on pain relief, mental state, safety and quality of life in the patients with moderate to severe cancer pain. Methods Eighty cancer patients were randomly divided into two groups with 40 cases in each group. The patients in the combined group received medical ozone combined with slow-release oxycodone, and the patients in the Oxycontin group only received slow-release oxycodone. Pain score, depression score, quality of life, drug dosage and adverse reactions before treatment, 2 weeks after treatment and 1 month after discharge were recorded. Results After treatment, the pain of the two groups were well controlled and had no significant difference. After 2 weeks of treatment and 1 month after discharge, the drug dosage of the combined group was lower than that of the Oxycontin group (P < 0.05). After 2 weeks of treatment and 1 month after discharge, the quality of life and depression of the combined group were significantly improved compared to the Oxycontin group (P < 0.05). There was no serious complication in the two groups. The incidences of nausea and vomiting, drowsiness and pruritus were higher in the Oxycontin group than in the combined group (P < 0.05). Conclusions In the treatment of moderate to severe cancer pain, medical ozone combined with slow-release oxycodone, can significantly improve the mood and quality of life of the patients, reduce the dosage of opioids and has no obvious complications. It is recommended to be used in clinic.