不同绝经年限及血脂代谢对绝经女性 跟骨骨密度影响

Effect of different menopausal years and blood lipid metabolism on calcaneus bone mineral density in postmenopausal women

摘要:

目的 探讨不同绝经年限及血脂代谢对绝经女性跟骨骨密度的关系。方法 选取2014 年11 月- 2016 年5 月在该院内分泌科进行体检的自然绝经后女性288 例。按绝经的不同年限随机分为绝经年限≤ 5 年 组、6 ～ 10 年组、11 ～ 15 年组、16 ～ 20 年组、21 ～ 25 年组及26 ～ 30 年组，分别收集6 组患者的三酰甘油、 总胆固醇、高密度脂蛋白、低密度脂蛋白及跟骨超声骨密度，分析不同绝经年限及血脂代谢与T 值及骨硬度 指数的关系。结果 不同绝经年限各组的骨密度T 值及骨硬度指数均随着绝经年限的延长而逐渐减小，差异有 统计学意义（P <0.05）；但不同绝经年限组组间的三酰甘油、总胆固醇、高密度脂蛋白、低密度脂蛋白的水平 无明显变化，差异无统计学意义（P >0.05）；总胆固醇、低密度脂蛋白与骨密度存在相关性（P <0.05）。结论 不同绝经年限与女性跟骨骨密度下降密切相关，是骨质疏松发生的高危因素，与血脂代谢相关。

Abstract:

Objective To investigate the relationship of menopausal years and lipid metabolism with calcaneus bone mineral density in postmenopausal women. Methods A total of 288 female cases after natural menopause, who had physical examination in the Department of Endocrinology of the First Affiliated Hospital of Guangxi Medical University from November 2014 to May 2016, were selected. According to different menopausal years they were randomly divided into 6 groups including a ≤ 5 years menopause group, a 6-10 years group, an 11-15 years group, a 16-20 years group, a 21-25 years group, and a 26-30 years group. Total cholesterol, triglyceride, high-density lipoprotein, low-density lipoprotein and calcaneus bone mineral density were determined. The relationships of different duration of menopause and lipid metabolism with T value and bone hardness index were analyzed. Results The bone mineral density index T value and bone hardness index of different groups of menopause decreased gradually with the prolongation of menopause duration, the differences were statistically significant (P < 0.05). However, there were no significant differences in the levels of triglyceride, total cholesterol, high-density lipoprotein or low-density lipoprotein among different menopausal year groups (P > 0.05). Total cholesterol and low-density lipoprotein were correlated with bone mineral density (P < 0.05). Conclusions The female menopause and calcaneus bone mineral density decline are the risk factors for osteoporosis occurrence, and also have relationships with lipid metabolism.