乳腺癌组织中Snail、Bcl-2 的 表达水平及其临床意义

Expressions of Snail and Bcl-2 in breast cancers and their clinical significance

摘要:

目的 探讨乳腺癌组织中Snail 和Bcl-2 蛋白的表达水平与临床病理特征及预后的相关性。 方法 使用免疫组织化学法分析2010 ～ 2015 年在该院就诊的92 例乳腺癌患者的癌组织中Snail 和Bcl-2 蛋 白表达水平，分析2 种蛋白表达的相关性，以及两者与患者临床病理特征及预后的关系。结果 乳腺癌组织 中Snail 高表达率为62.5%，Bcl-2 低表达率为57.6%，与癌旁组织蛋白表达率比较有差异（P <0.05），乳腺癌 组织中Snail 与Bcl-2 呈负相关（P <0.05）；Snail 表达水平与组织学分级、淋巴结是否转移、雌激素受体（ER） 及孕激素受体（PR）表达有相关性（P <0.05），Bcl-2 表达水平与肿瘤大小、ER 及PR 有相关性（P <0.05）； 低表达Snail 乳腺癌患者无瘤生存率为87.5%，死亡1 例；高表达Snail 乳腺癌患者无瘤生存率为78.3%，死亡5 例， 差异有统计学意义（P <0.05）；高表达Bcl-2 乳腺癌患者无瘤生存率为87.2%，死亡1 例，低表达Bcl-2 乳腺 癌患者无瘤生存率为77.4%，死亡5 例，差异有统计学意义（P <0.05）。结论 Snail 表达水平与乳腺癌进展呈 正相关，Bcl-2 表达水平与乳腺癌进展呈负相关，而高表达Snail 和低表达Bcl-2 患者预后较差。

Abstract:

Objective To investigate the expressions of Snail and Bcl-2 in breast cancers and their correlations with clinicopathological features and prognosis. Methods The expressions of Snail and Bcl-2 proteins in 92 patients with breast cancers treated in our hospital from 2010 to 2015 were analyzed by immunohistochemical method. The correlation between Snail and Bcl-2 protein expressions was analyzed, and their relationships with clinicopathological features and prognosis were analyzed. Results The high expression rate of Snail was 62.5% and the low expression rate of Bcl-2 was 57.6% in the breast cancer tissues, which were significantly higher than those in the paracancerous tissues (P < 0.05). There was a negative correlation between Snail and Bcl-2 expressions in the breast cancer tissues (r = -0.519). In addition, the expression level of Snail was correlated with pathological stage, lymph node metastasis and the positive expressions of estrogen receptor (ER) and progesterone receptor (PR) (P < 0.05); the expression of Bcl-2 was correlated with histological grade, ER and PR (P < 0.05). In the breast cancer patients with low expression of Snail, the disease-free survival rate was 87.5%, 1 case died; while in the breast cancer patients with high expression of Snail, the disease-free survival rate was 78.3% , 5 cases died; the differences were significant (P < 0.05). The disease-free survival rate of the breast cancer patients with high expression of Bcl-2 was 87.2%, 1 case died; while the disease-free survival rate of the breast cancer patients with low expression of Bcl-2 was 77.4%, 5 cases died, there were statistically significant differences (P < 0.05). Conclusions Snail and breast cancer progression are positively correlated, Bcl-2 and breast cancer progression are negatively correlated. The patients with high expression of Snail and low expression of Bcl-2 have poor prognosis.