乙肝相关肝癌根治术后复发再切除的生存研究

Survival analysis of Hepatitis B virus -related hepatocellular carcinoma after re-resection

摘要:

目的 分析乙肝相关肝细胞癌患者根治术后，发生肝内早期或晚期复发患者的生存率及再切除后 的生存率差异。方法 回顾性分析2005 年3 月-2009 年8 月贵州医科大学附属医院收治的乙肝相关肝癌患 者35 例，所有患者已行肝癌根治术，术后随访发现肝内复发行再切除术。其中，早期复发17 例；晚期复发18 例。 比较早期与晚期复发患者首次切除术后的生存率及再切除术后的生存率。结果 晚期复发患者首次切除术后 的生存率优于早期复发患者（P <0.05），而两组复发再切除后的生存率比较，差异无统计学意义（P >0.05）。 结论 乙肝相关肝癌患者早期与晚期复发再切除的生存率无明显差异。

Abstract:

Objective To investigate the survival rate of the patients with early recurrence or late recurrence of Hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) after radical resection and the difference of survival rate after re-resection. Methods Thirty-five patients with HBV-related HCC treated in our hospital from March 2005 to August 2009 were retrospectively reviewed. All patients received radical hepatectomy for the treatment of HCC, and liver re-resection when intrahepatic recurrence was diagnosed during follow-up. Among them, 17 had early recurrence, and 18 had late recurrence. Overall survival (OS) was analyzed between both groups. Results The OS of the late recurrence patients after the first radical resection was better than that of the early recurrence patients (P < 0.05). However, the OS after re-resection was not significantly different between the two groups of patients (P > 0.05). Conclusions The OS is not significantly different after re-resection between the early recurrence patients and the late recurrence patients.