慢性丙型肝炎病毒患者APRI 评分与 肝功能、凝血功能的相关性

Correlations of aspartate aminotransferase-to-platelet ratio index with liver function and coagulation function in chronic hepatitis C patients

摘要:

目的 探讨不同程度肝损伤慢性丙型肝炎病毒（HCV）患者天门冬氨酸氨基转移酶与血小板比 值（APRI）评分、肝功能及凝血功能之间的关系。方法 检测受试者的肝功能、血小板及凝血功能指标，计 算APRI 评分，对相关指标进行比较分析。结果 HCV 组患者血浆纤维蛋白原（FIB）、APRI 评分、总胆红 素（TBIL）、γ- 谷氨酰转肽酶（γ-GT）、活化部分凝血活酶时间（APTT）、凝血酶原时间（PT）、凝血酶 时间（TT）及D 二聚体（D-D）水平与健康体检组比较有差异（P <0.05）。患者TBIL、γ-GT、APTT、 PT 及TT 与APRI 评分呈正相关（P <0.05），FIB 与APRI 评分呈负相关（P <0.05）。结论 慢性HCV 患者 肝功能、凝血功能与APRI 评分相关，对评估慢性HCV 患者肝损伤趋势有重要意义。

Abstract:

Objective To approach the correlation between liver function, blood coagulation function and aspartate aminotransferase-to-platelet ratio index (APRI) in chronic hepatitis C patients with different degrees of liver injury. Methods Liver function, platelet and blood coagulation function were detected by automation instruments, and then APRI was calculated. The related indexes were analyzed and compared. Results The levels of plasma fibrinogen (FIB), APRI, total bilirubin (TBIL), gamma-glutamyl transpeptidase (γ-GT) and D-dimer, and activated partial thromboplastin time (APTT), prothrombin time (PT) and thrombin time (TT) were significantly different between the patients and the healthy controls (P < 0.05). The result of correlation analysis showed that TBIL, γ-GT, APTT, PT and TT were positively correlated with APRI (P < 0.05), while FIB had a negative correlation with APRI (P < 0.05). Conclusions Liver function and coagulation function have correlations with APRI in chronic hepatitis C patients, and all of the indexes have important clinical significance in evaluation of the extent of liver injury in the patients.