PCI 前r h-BNP 预处理对急性心肌梗死 患者的疗效分析

Influence of rh-BNP preconditioning combined PCI therapy on cardiac function of AMI patients

摘要:

目的 分析重组人脑利钠肽（rh-BNP）预处理联合冠状动脉介入（PCI）对急性心肌梗死患者 术后心功能的影响。方法 对照组患者接受常规PCI 术治疗，观察组患者接受rh-BNP 预处理联合PCI 治疗。 对比两组患者的心室重构指标、心功能指标及血清相关指标值差异。结果 观察组患者手术后3 个月的左室 舒张末期内径、室间隔厚度、左室后壁厚度、左室重量指数、左室收缩末期容积及左室舒张末期容积值低 于对照组患者（P <0.05），而左室射血分数、二尖瓣血流舒张早期流速/ 心房收缩期流速值高于对照组患者 （P <0.05），观察者患者手术后血清氨基末端B 型利钠肽前体、Ⅲ型前胶原氨基末端肽及心型脂肪酸结合蛋白 低于对照组患者（P <0.05）。结论 PCI 术前rh-BNP 预处理可以增强AMI 患者的心功能，有助于远期治疗 结局的优化。

Abstract:

Objective To analyze the influence of recombinant human brain natriuretic peptide (rh- BNP) preconditioning combined percutanous coronary intervention (PCI) therapy on AMI patients’ cardiac function. Methods Seventy-eight patients with AMI were included in the study, and divided into an observation group and a control group according to the random number table method, each with 39 patients. The patients of the control group received conventional PCI treatment, and the patients in the observation group received rh-BNP preconditioning combined PCI treatment. The changes in the values of ventricular remodeling indexes, cardiac function and serum related indexes were compared between the two groups. Results The values of left ventricular end diastolic diameter (LVDd), interventricular septum thickness (IVST), left ventricular posterior wall thickness (LVPWT), left ventricular mass index (LVMI), left ventricular end systolic volume (LVESV), and left ventricular end diastolic volume (LVEDV) in the observation group were lower than those in the control group; the values of left ventricular ejection fraction (LVEF), and mitral valve early diastolic blood flow rate (VE)/atrial systolic flow velocity (VA) were higher than those of the control group (P < 0.05); the values of serum N-terminal-pro-B-type natriuretic peptide, type Ⅲ procollagen, and heart fatty acid binding protein were lower than those of the control group (P < 0.05). Conclusions rh-BNP preconditioning combined PCI therapy can enhance the cardiac function of AMI patients, and optimize the long-term treatment outcomes.