小檗碱对精神分裂症患者认知功能 及相关因子的影响

Effect of Berberine on cognition and related factors of schizophrenia

摘要:

目的 探讨小檗碱对精神分裂症患者认知功能、神经营养和神经炎性损伤的影响。方法 选择 2014 年1 月-2016 年12 月该院精神分裂症患者140 例，根据随机数表字法分为小檗碱组（小檗碱+ 奥氮平 治疗）和对照组（安慰剂+ 奥氮平治疗），每组70 例。采用精神分裂症认知功能成套测验中文版检测精神分 裂症患者的认知功能，酶联免疫吸附法测定血清神经营养因子-3（NT-3）、脑源性神经营养因子（BDNF）， 以及血清白细胞介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）、白细胞介素-1β（IL-1β）、C 反应蛋白 （CRP）水平。结果 治疗前，小檗碱组与对照组HVLT-R 总分、WMS- Ⅲ总分、BVMT-R 总分、TMT 评分、SC 评分，以及血清NT-3、BDNF、IL-6、TNF-α、IL-1β、CRP 水平比较，差异无统计学意义 （P >0.05）。治疗后，小檗碱组HVLT-R 总分、WMS- Ⅲ总分、BVMT-R 总分、SC 评分高于对照组（P <0.05）， TMT 评分低于对照组（P <0.05）；小檗碱组血清NT-3 和BDNF 水平高于对照组（P <0.05），血清IL-6、 TNF-α、IL-1β、CRP 水平低于对照组（P <0.05）。结论 小檗碱可改善精神分裂症患者认知功能，具有 神经保护作用，可降低神经炎性反应。

Abstract:

Objective To investigate the effect of Berberine on cognitive function, neurotrophy and neuroinflammatory injury in schizophrenia patients. Methods A total of 140 cases of schizophrenia patients were selected in Hangzhou Seventh People’s Hospital from January 2014 to December 2016, and were randomly divided into a Berberine group (Berberine+Olanzapine treatment) and a control group (placebo+Olanzapine treatment), with 70 cases in each group. The Chinese version of schizophrenia cognitive function test was used to test the cognitive function of the patients. Enzyme-linked immunosorbent assay (ELISA) was used to determine the serum levels of neurotrophic factor 3 (NT-3), brain-derived neurotrophic factor (BDNF), interleukin 6 (IL-6), tumor necrosis factor α (TNF-α), interleukin-1β (IL-1β), and C-reactive protein (CRP). Results Before treatment, there were no significant difference in the total score of HVLT-R, WMS-Ⅲ, BVMT-R, TMT or SC, or the serum level of NT-3, BDNF, IL-6, TNF-α, IL-1β or CRP (P > 0.05). After treatment, the total scores of HVLT-R, WMS-Ⅲ, BVMT-R and SC in the Berberine group were higher than those in the control group (P < 0.05), the TMT score was lower than that in the control group (P < 0.05); the serum levels of NT-3 and BDNF in the Berberine group were higher than those in the control group (P < 0.05); the serum levels of IL-6, TNF-α, IL-1β and CRP in the Berberine group were lower than those in the control group (P < 0.05). Conclusions Berberine can improve cognitive function of schizophrenia patients and reduce the neuroinflammatory response, and has neuroprotective effect.