右美托咪定对胃癌手术患者认知功能及 血清IL-6 和PI3K/AKT 表达的影响

Effects of Dexmedetomidine on cognitive function in patients with gastric cancer

摘要:

目的 探讨右美托咪定对胃癌手术患者认知功能保护作用及对患者血清IL-6 及PI3K/AKT 表达 的影响。方法 选取该院收治的80 例胃癌手术患者作为研究对象，按入院先后顺序分为右美组和对照组，每 组各40 例。对照组患者采用静吸复合麻醉方法，在该基础上右美组患者加用右美托咪定。比较两组患者术后 认知功能、血清IL-6 及PI3K、AKT 表达水平。结果 右美组患者术后1 d MMSE 评分高于对照组患者，差 异有统计学意义（P <0.05）；术后24 h 及术后3 d，对照组患者血清IL-6 及PI3K、AKT 水平高于右美组患 者，差异有统计学意义（P <0.05）；患者MMSE 评分与血清IL-6、PI3K、AKT 表达水平呈负相关（P <0.05）。 结论 右美托咪定可有效保护胃癌患者术后认知功能，其机制可能与IL-6 介导的PI3K/AKT 信号通路有关。

Abstract:

Objective To investigate the protective effect of Dexmedetomidine on cognitive function in patients with gastric cancer. Methods Totally 80 cases of gastric cancer were involved and divided randomly into control group and observation group (n = 40). All patients were treated with intravenous anesthesia combined with inhalation anesthesia, and patients in the observation group received additional Dexmedetomidine. Levels of cognitive function, serum IL-6, PI3K and AKT were determined. Results Score of MMSE in observation group was higher significantly compared with control group on the 1st day after operation (P < 0.05). Levels of IL-6, PI3K and AKT in the control group were enhanced dramatically when compared with that in observation group at the 24th h and the 3rd day after operation (P < 0.05). MMSE score was negatively correlated with the levels of IL-6, PI3K and AKT (P < 0.05). Conclusion Dexmedetomidine effectively protects the postoperative cognitive function of patients with gastric cancer through modulating IL-6-mediated PI3K/AKT signaling pathway.