消瘀泄浊饮对糖尿病肾病肾衰竭患者 血清瘦素的影响

Effect of Xiaoyuxiezhuoyin on serum leptin in diabetic patients with renal failure

摘要:

目的 消瘀泄浊饮对糖尿病肾病（DN）慢性肾脏病（CKD）3~5 期患者血清瘦素（LP）干预作用。 方法 按随机原则将80 例DN CKD3~5 期患者分为治疗组和对照组，每组各40 例。对照组予以西医常规治疗； 治疗组在对照组基础上采用消瘀泄浊饮治疗，1 剂/d，两组疗程均为3 个月。检测治疗前后LP 进行主要症状评 分。结果 两组治疗后LP 下降，治疗组LP 水平低于对照组（P <0.05）；治疗组治疗后主要症状、体征积分低于 对照组（P <0.05）。结论 在西医常规基础上，消瘀泄浊饮对DN CKD3~5 期患者肾功能有一定的保护作用，延 缓肾衰竭的进程。

Abstract:

Objective To investigate the effect of Xiaoyuxiezhuoyin on serum leptin (LP) in diabetic patients with CKD3-5 renal failure. Methods Totally 80 diabetic patients with CKD3-5 renal failure were randomly divided into observation group and control group (n = 40). All patients were treated with standard medical therapy. Patients in observation group received additional Xiaoyuxiezhuoyin (1 dose per day for 3 months). Concentration of LP was measured priorpre to and post treatment. Main symptom scores were recorded. Results Patients in observation group experienced more dramatical reduction of LP compared with that in control group, though concentration of LP was decreased in control group (P < 0.05). scores of main symptoms and signs in observation group were improved significantly when compared with control group (P < 0.01). Conclusion Xiaoyuxiezhuoyin exerts renal protection in diabetic patients with CKD3-5 kidney failure, alleviating clinical symptoms and progression of renal failure.