男性血清维生素D 与生殖激素的关联性研究

Correlation between serum vitamin D and reproductive hormone in male human beings

摘要:

目的 了解石家庄地区血脂异常男性血清25- 羟基维生素D3[25（OH）VD3] 水平变化以及与生殖 激素的关系。方法 选取25 ～ 65 岁男性297 例，按血脂水平分为对照组（145 例）和高脂组（152 例）。按年龄 分为≥ 25 ～ <35 岁、≥ 35 ～ 45 岁、≥ 45 ～ 55 岁及≥ 55 ～ 65 岁4 个年龄组，依据血清25（OH）VD3 水平 的三分位数分为3 组（Q1 组、Q2 组及Q3 组）；检测血脂、血糖、25（OH）VD3 及生殖激素等。结果 同年 龄段高脂组男性25（OH）VD3 水平低于对照组（P <0.05）。随着年龄的增长，对照组和高脂组男性血清25（OH） VD3 逐渐下降，相邻年龄组间比较，差异有统计学意义（P <0.05）；Q2 组和Q3 组的睾酮（T）水平高于Q1 组， Q3 组T 水平高于Q2 组（P <0.05）。血清25（OH）VD3 与年龄、腰围（WC）、体重指数（BMI）及三酰甘油（TG） 呈负相关，与T 呈正相关（P <0.05）；多元线性回归分析显示，年龄和TG 是25（OH）VD3 的影响因素（P <0.05）。 结论 高血脂男性血清25（OH）VD3 水平普遍下降，且随年龄的增长而降低。T 水平下降是低水平血清25（OH） VD3 的伴随因素。

Abstract:

Objective To investigate correlation between serum vitamin D3 [25 (OH) VD3] and reproductive hormone in dyslipidemic men in shijiazhuang. Method Totally 297 adult male aged from 25 to 65 years old were enrolled in this study. Patients were divided into normal group (n = 145) and high lipid group (n = 152) based on blood lipid levels. Based on age, patients were sub-grouped into four groups: 25-35 group, 36-45 group, 46-55 group and 56-65 group. Patients were sub-grouped into three groups (Q1, Q2, Q3) based on levels of serum 25 (OH) VD3. Results Patients with high lipid levels had increased levels of [25 (OH) VD3] in the same age group when compared with normal group, though all individuals experienced decrease of [25( OH) VD3] along with aging (P < 0.05). Levels of testosterone (T) was upregulated along with the increase of concentration of 25(OH) VD3 (P < 0.05). Spearman correlation analysis revealed that [25 (OH) VD3] was negatively correlated with age, WC, BMI, and TG while positively correlated with T. Regression analysis showed that age and TG were independent risk factors for concentration of [25 (OH) VD3]. Conclusion Patients with high lipid experience decreased levels of serum [25 (OH)VD3] along with aging while decrease of testosterone is a risk factor for [25 (OH) VD3] deficiency.