血小板相关参数在慢性阻塞性肺疾病 患者中的变化及意义

Decreased levels of platelets in COPD patients

摘要:

目的 探究血小板在COPD 患者与健康人之间是否存在差异及血小板相关参数变化的临床意义。 方法 选择该院122 例初次入院被确诊为COPD 且排除血液、肿瘤、肺血栓栓塞症等相关疾病的COPD 住院 患者作为COPD 组，以性别、年龄、民族相匹配的该院同期健康体检者122 例作为对照组，收集两组的临床资 料及首次血常规检查结果。结果 COPD 组血小板计数为（193.85±66.68）×109/L、血小板与中性粒细胞比 值为（48.97±25.15），对照组分别为（ 210.45±37.38）×109/L、（60.96±16.79），两组比较差异有统计学意义 （P <0.05）；COPD 组平均血小板体积、血小板与淋巴细胞比值、中性粒细胞计数、白细胞计数均高于对照组 （P <0.05），而血小板体积分布宽度、淋巴细胞计数、红细胞计数均低于对照组（P <0.05）；血小板比容、嗜酸 性粒细胞计数两组间差异无统计学意义（P >0.05）。血小板计数与气流受限严重程度不存在相关性（r s=-0.104， P =0.252）；血小板与中性粒细胞比同气流受限严重程度无相关（r s=-0.070，P =0.444）；血小板与淋巴细胞 比同气流受限严重程度不存在相关（r s=0.132，P =0.147）；嗜酸性粒细胞计数与气流受限严重程度呈负相关 （r s=-0.267，P =0.003）。结论 COPD 患者血小板计数、血小板与中性粒细胞比值均降低，血小板计数、血小 板与中性粒细胞比值同CODP 患者疾病严重程度无关。

Abstract:

Objective To investigate the difference in platelets between COPD patients and healthy individuals. Methods Totally 122 patients admitted to the hospital with COPD were involved as COPD group in this study. Subjects diagnosed with blood diseases, tumor, pulmonary thromboembolism and other related diseases were excluded. Totally 122 healthy subjects matched with gender, age, and nationality were selected as control group. Clinical data and laboratory results were collected. Results Patients in COPD group experienced decreased levels of platelet and ratio of platelet over neutrophils when compared with control group [(193.85 ± 66.68) × 109/L vs (210.45 ± 37.38) × 109/L, (48.97 ± 25.15) vs (60.96 ± 16.79), P < 0.05]. Mean platelet volume, ratio of platelet over lymphocyte, neutrophil and white blood cell count group were upregulated while platelet volume distribution width,lymphocyte and red blood cell countwere down-regulated in COPD group compared with those in control group (P < 0.05). There was no statistically significant difference in platelet specific volume and eosinophil count between two groups (P > 0.05). No obvious correlation was identified either between platelet count and severity of airflow limitation, ratio of platelet over neutrophil and severity of airflow limitation, or ratio of platelet over lymphocyte and severity of airflow limitation [(rs = -0.070, P = 0.444), (rs = -0.104, P = 0.252), (rs = 0.132, P = 0.147), respectively]. Eosinophil count was negatively correlated with severity of airflow limitation (rs = -0.267, P = 0.003). Conclusions Platelet count and ratio of platelet over neutrophil are decreased in COPD patients, though none of which are related to the severity of CODP.