影响陕北地区毛囊移植术患者 毛囊成活率的因素分析

Factor analysis of hair follicle survival rate in patients with hair follicle transplantation from Northern Shaanxi

摘要:

目的 探讨影响陕北地区毛囊移植术患者毛囊成活率的因素。方法 选取2012 年1 月-2015 年12 月该院接受毛囊移植术治疗的陕北地区秃发患者152 例。根据患者毛囊移植术术后毛囊成活率分为毛囊成活率 ≥ 90% 组（96 例）和毛囊成活率<90% 组（56 例）。比较两组性别、年龄、体重指数（BMI）、吸烟史、嗜酒史、 头皮切口方向、毛囊种植密度、睾酮、二氢睾酮、脱氢异雄酮、雄烯二酮、肾上腺素使用剂量、毛囊分离质量、 毛囊存放区温度、毛囊体外保存液、毛囊离体时间、毛囊单位体外培养模型、术后激光治疗情况及术后米诺 地尔使用情况等。结果 毛囊成活率≥ 90% 组雄激素水平低于毛囊成活率<90% 组（P <0.05）；0.2 ～ 0.3 ml 肾上腺素使用剂量、0 ～ 4℃毛囊存放区温度、使用该中心保存液、0 ～ 2 h 得毛囊离体时间、保留组织的单 根毛发毛囊单位体外培养模型、术后使用激光治疗及术后使用米诺地尔的毛囊成活率≥ 90% 组秃发患者比例 更高（P <0.05）。睾酮水平偏高、二氢睾酮水平偏高、脱氢异雄酮水平偏高、雄烯二酮水平偏高、未使用该 中心毛囊体外保存液、去除组织的单根毛发毛囊单位体外培养模型、术后未激光治疗及术后未使用米诺地尔 不利于陕北地区毛囊移植术患者毛囊成活（P <0.05）。结论 陕北地区毛囊移植术患者毛囊成活率与其雄激素 水平、毛囊体外保存液、单根毛发毛囊单位体外培养模型、激光治疗及米诺地尔使用等因素密切相关，临床 医师应密切注意。

Abstract:

Objective TTo investigate the factors affecting the survival rate of hair follicles in hair follicle transplantation from Northern Shaanxi. Methods A total of 152 patients with alopecia in our hospital from January 2012 to December 2015 were selected. The subjects were divided into ≥ 90% group (n = 96) and < 90% group (n = 56) depending on hair follicle survival rate. Gender, age, body mass index (BMI), differences in smoking history, history of alcohol, scalp incision direction, hair follicle density, testosterone, dihydrotestosterone, transdehydroandrosterone, androstendione, adrenaline dose, hair follicle isolation quality, hair follicle storage area temperature, hair follicle preservation solution, hair follicle in vitro time, hair follicle unit in vitro culture model, laser treatment after operation, and the postoperative use of Minoxidil were compared between the groups. Results The androgen level in ≥ 90% group was lower than that in < 90% group (P < 0.05); the levels of 0.2 -0.3 ml adrenaline dose, 0.6 -0.8 mm diameter, temperature of hair follicle storage area at 0-4 ℃, usage of preservation solution of the center, 0 -2 h of hair follicles in vitro, retention time of single hair follicle unit in vitro tissue culture model, the use of laser therapy and postoperative use of Minoxidil survival rate of the hair were higher in ≥ 90% group (P < 0.05). Multivariate Logistic regression analysis showed that these factors including high levels of testosterone, dihydrotestosterone, transdehydroandrosterone and androstendione, unused hair follicle preservation solution in the center, tissue culture model of single hair follicle unit in vitro, laser-free treatment after operation and unused Minoxidil after operation were not conducive to hair follicle survival in patients with hair follicle transplantation in Northern Shaanxi (P < 0.05). Concluson The survival rate of hair follicles in patients with hair follicle transplantation in Northern Shaanxi is closely related to the level of androgen, hair follicle in vitro preservation liquid, single hair follicle unit in vitro model, laser treatment and the use of Minoxidil.