乳腺癌组织磁共振T2WI 信号特征与增殖细胞核 抗原（Ki-67）表达的相关性

Correlation between signal characteristics of MRI T2WI and expression of proliferating cell nuclear antigen (Ki-67) in breast cancer

摘要:

目的 探讨乳腺癌患者磁共振（MRI）T2WI 信号特征与细胞核增殖抗原（Ki-67）表达的相关性。 方法 采用回顾性与随机抽样研究方法，选取2011 年9 月-2017 年4 月在该院诊治的乳腺癌患者122 例作为研 究对象，记录MRI T2WI 信号特征与扩散加权成像（DWI）表观弥散系数（ADC）值，采用免疫组织化学检测Ki- 67 阳性表达情况。结果 癌组织的Ki-67 阳性率为54.9%，癌旁组织为23.8%，癌组织的Ki-67 阳性率高于癌旁 组织（P <0.05）。在T2WI 信号特征上，癌组织78 例（63.9%）主要表现为高信号与高亮信号，癌旁组织9 例（7.4%） 主要表现为低或等信号。癌组织的ADC 值为（0.89±0.12）×10-3/mm2，低于癌旁组织的（1.67±0.24）×10-3/ mm2（ P <0.05）。在癌组织中，Spearman 相关性系数分析显示T2WI 高信号与Ki-67 阳性率呈正相关（r s =0.724， P <0.05），与ADC 值呈负相关（rs =-0.452，P <0.05）。多因素分析T2WI 高信号、ADC 值为影响Ki-67 阳性 率的危险因素（P <0.05）。结论 乳腺癌病灶MRI T2WI 信号特征多表现为高信号，Ki-67 呈现高阳性率表达， 伴随有ADC 值下降，它们之间存在相关性，T2WI 信号特征对乳腺癌的筛查及预后判断有积极作用。

Abstract:

Objective To investigate the correlation between signal characteristics of magnetic resonance imaging (MRI) T2WI and the expression of proliferating cell nuclear antigen (Ki-67) in breast cancer. Methods A total of 122 cases of breast cancer in our hospital were selected from September 2011 to April 2017 with a retrospective study of random sampling method. T2WI signals characteristics and DWI ADC values of breast cancer were recorded, immunohistochemical detection of Ki-67 was done. Results The positive rate of Ki-67 in cancer and adjacent tissues was 54.9% and 23.8%, respectively. The positive rate of Ki-67 in cancer tissues was higher than that in adjacent tissues (P < 0.05). T2WI signal characteristics of the cancer tissues (78 cases, 63.9%) were mainly high or high light signals, while were mainly low or equal ones for adjacent tissues (9 cases, 7.4%) . The ADC value in cancer tissues was (0.89 ± 0.12 × 10-3/mm2), which was lower than that (1.67 ± 0.24 × 10-3/mm2) in the adjacent tissues (t = 10.382, P < 0.05). In cancer tissues, Spearman correlation coefficient analysis showed there was positive correlation between T2WI high signal and Ki-67 positive rate (rs = 0.724, P < 0.05), while T2WI high signal was negatively correlated with ADC value (rs = -0.452, P < 0.05). Multivariate analysis showed that the T2WI high signal and ADC value were also the independent risk factors of Ki-67 positive rate (P < 0.05). Conclusion In breast cancer, signal of MRI T2WI is mostly high; expression rate of Ki-67 is high and is negatively correlated with ADC. T2WI signal characteristics can be used for breast cancer screening and prognosis.