硫辛酸对2 型糖尿病合并骨质疏松患者 骨代谢的影响

Effect of adjuvant therapy of thioctic acid on bone metabolism in patients of type 2 diabetes mellitus complicated with osteoporosis

摘要:

目的 探讨硫辛酸辅助治疗2 型糖尿病（T2DM）合并骨质疏松的疗效及对骨代谢水平的影响。 方法 选取2015 年1 ～ 12 月于兴义市人民医院接受治疗的160 例T2DM 合并骨质疏松作为研究对象，按照 随机数字表法随机分为对照组和观察组，每组各80 例。对照组患者给予常规治疗，观察组患者在对照组基 础上给予硫辛酸辅助治疗。3 个月后，比较组间骨质疏松临床疗效、骨密度（BMD）及骨代谢水平。结果 3 个月后，骨质疏松临床疗效显示，观察组患者总有效率与对照组比较（91.2% vs 80.0%），差异有统计学意义 （P <0.05），观察组高于对照组。治疗后，两组腰椎、股骨颈BMD、骨碱性磷酸酶（BALP）、空腹血骨钙素（BGP） 水平、人胶原交联羧基末端肽（CTX）水平比较，差异有统计学意义（P <0.05），观察组患者腰椎、股骨颈 BMD 升高，BALP、BGP 水平升高，CTX 水平下降。结论 硫辛酸辅助治疗在T2DM 合并骨质疏松中应用效 果良好，治疗有效率高，能够改善患者临床症状，增加骨密度，并且能够改善骨代谢，值得临床上进一步研究。

Abstract:

Objective To investigate the curative efficacy of thioctic acid in treating type 2 diabetes mellitus (T2DM) patients complicated with osteoporosis and its effect on bone metabolism. Methods Totally 160 T2DM patients complicated with osteoporosis who received therapy in our hospital from January to December 2015 were selected as research objects. According to random number table method, the patients were randomly divided into two groups with equal number. The control group was given conventional treatment. Besides that, the observation group was given adjuvant therapy of thioctic acid. After 3 months, curative effect on osteoporosis, bone mineral density (BMD) and level of bone metabolism were compared between the two groups. Results The total effective rate of treating osteoporosis in the observation group was statistically higher than that in the control group (91.2% vs. 80.0%, P < 0.05). After the treatment, in comparison with the control group, the observation group had statistically higher BMD levels of lumbar vertebrae and collum femoris (P < 0.05). As to bone metabolism, the observation group had statistically higher levels of bone alkaline phosphatase (BALP), fasting bone gla protein (BGP) and statistically lower level of human cross-linked carboxy-terminal telopetide of collagen (CTX) than the control group (P < 0.05). Conclusions Adjuvant therapy of thioctic acid is effective in treating T2DM patients complicated with osteoporosis with a high therapeutic effective rate. And it can significantly improve the clinic symptoms, increase BMD and improve bone metabolism.