复方丹参片联合多奈哌齐治疗阿尔茨海默病的 临床疗效研究

Study of compound Danshen tablets combined with Donepezil on Alzheimer's disease

摘要:

目的 探讨复方丹参片联合多奈哌齐治疗阿尔茨海默病（AD）的安全性和有效性。方法 选取广 西壮族自治区江滨医院AD 患者共100 例，随机数字表法分为观察组和对照组，每组50 例。对照组给予多奈 哌齐治疗，观察组给予复方丹参片联合多奈哌齐治疗。观察组与对照组治疗前、治疗后1 个月、治疗后3 个 月的简易精神状态量表（MMSE）评分、AD 认知功能评定量表（ADAS-cog）评分、日常生活能力量表（ADL） 评分、血清谷氨酸（Glu）水平、血清天冬氨酸（Asp）水平，均采用重复测量设计的方差分析。统计不良反 应发生率。结果 ①不同时间点间的MMSE 评分、ADAS-cog 评分、ADL 评分、血清Glu 水平、血清Asp 水平 有差异（P <0.05）。②观察组与对照组的MMSE 评分、ADAS-cog 评分、ADL 评分、血清Glu 水平、血清Asp 水平有差异（P <0.05），观察组与对照组比较MMSE 评分较高，ADAS-cog 评分、ADL 评分、血清Glu 水 平、血清Asp 水平较低。③观察组与对照组的MMSE 评分、ADAS-cog 评分、ADL 评分、血清Glu 水平、血 清Asp 水平变化趋势有差异（P <0.05）。观察组和对照组不良反应发生率比较，差异无统计学意义（P <0.05）。 结论 复方丹参片联合多奈哌齐治疗AD 的效果确切，其机制可能与抑制兴奋性氨基酸表达有关。

Abstract:

Objective To evaluate the efficacy and safety of compound Danshen tablets combined with Donepezil on Alzheimer's disease (AD). Methods One hundred AD patients were randomly divided into an observation group and a control group, with 50 cases in each group. The control group was treated with Donepezil, and the observation group was treated with compound Danshen tablets combined with Donepezil. Before treatment, 1 month and 3 months after treatment, Mini-mental State Examination (MMSE) score, Alzheimer’s Disease Assessment Scale (ADAS-cog) score, activities of daily living (ADL) score, glutamic acid (Glu) level and aspartic acid (Asp) level of the two groups were analyzed by repeated measures. The incidences of adverse reactions of the two groups were counted. Results The MMSE score, ADAS-cog score, ADL score, serum Glu and Asp levels were different at different time points (P < 0.05). The MMSE score, ADAS-cog score, ADL score, serum Glu and Asp levels were different between the observation group and the control group (P < 0.05), the MMSE score of the observation group was higher than that of the control group, while the ADAS-cog score, ADL score, serum Glu and Asp levels of the observation group were lower than those of the control group. The variation trends of MMSE score, ADAS-cog score, ADL score, serum Glu and Asp levels were different at different time points (P < 0.05). The adverse reaction rate was not statistically different between the two groups (P > 0.05). Conclusions Compound Danshen tablets combined with Donepezil is effective for AD, its mechanism may be related to the inhibition of excitatory amino acid expression.