呼出气一氧化氮检测在变应性支气管 肺曲霉菌病随访中的价值

Value of FeNO in follow-up of allergic bronchopulmonary aspergillosis

摘要:

目的 探讨呼出气一氧化氮（FeNO）浓度检测在变应性支气管肺曲霉菌病随访中的临床价值。方 法 回顾性分析2013 年1 月-2016 年1 月北京朝阳医院和北京大学国际医院呼吸科确诊的变应性支气管肺曲霉 菌病且同时检测过血清过敏原总IgE 和FeNO 水平的患者15 例，根据患者临床症状及治疗反应分为加重期和非 加重期，比较血清总IgE 和FeNO 水平在不同时期的差异以及在同一患者中不同时期的变化幅度。结果 15 例 纳入患者中，男性5 例，女性10 例；年龄（51.67±13.95）岁。其中3 例患者有多次检测数据，最后符合加 重期的为12 例次，符合非加重期的为8 例次，加重期与非加重期的血清总IgE 水平差异无统计学意义（P > 0.05），加重期的FeNO 水平高于非加重期（P <0.05）。结论 FeNO 水平可作为判断变应性支气管肺曲霉菌病 患者是否处于加重期的预测因素之一，在治疗随访过程中具有重要价值。

关键词:变应性支气管肺曲霉菌病;呼出气一氧化氮;总IgE

Abstract:

Objective To investigate the clinical value of fractional exhaled nitric oxide (FeNO) measurement in the follow-up of allergic bronchopulmonary aspergillosis (ABPA). Methods The retrospective analysis was carried out in 15 patients who were diagnosed as ABPA in Beijing Chaoyang Hospital and International Hospital of Peking University from January 2013 to January 2016 and whose total IgE of serum allergens and FeNO level had been tested. Two stages (aggravating stage and non-aggravating stage) were set according to the patients’ symptoms and treatment reaction to Glucocorticoid. Total IgE and FeNO level were compared between the different stages. Results A total of 15 patients were enrolled. There were 10 female cases and 5 male cases with the average age of (51.67 ± 13.95) y. The FeNO level in the aggravating stage was higher than that in the non-aggravating stage (P < 0.05). The total IgE level was not significantly different between the two stages (P > 0.05). Conclusions FeNO level might be an predictive factor for assessment of aggravation of allergic bronchopulmonary aspergillosis patients. It has important value in ABPA treatment and follow-up.

Key words:allergic bronchopulmonary aspergillosis; fractional exhaled nitric oxide; total IgE