Objective To explore the clinical significance of argon plasma coagulation combined with cryotherapy in the treatment of endobronchial hamartoma. Methods A retrospective analysis was conducted in 6 inpatients with endobronchial hamartoma pathologically diagnosed between April 2008 and October 2016 in the Xianyang Central Hospital. BF-F260 fluorescence bronchoscope was used in argon plasma coagulation combined with cryotherapy for treatment of the patients. The therapeutic efficacy was assessed by computed tomography and bronchoscopy. Results In the 6 patients, 5 were males and 1 was female. After treatment, the endobronchial hamartoma disappeared and bronchial lumen became patent. There was no complication such as hemoptysis or pneumothorax. Conclusions Interventional therapies through flexible bronchoscope appear to be safe and effective for removing endobronchial hamartoma.