CXCR4 和CXCR7 在肾透明细胞癌 组织中的表达及其临床意义

Expressions of CXCR4 and CXCR7 in renal clear cell carcinoma and clinical significance

摘要:

目的 探讨趋化因子受体4（CXCR4）蛋白和趋化因子受体7（CXCR7）蛋白在肾透明细胞癌 （ccRCC）组织中的表达及其相关性。方法 采用免疫组织化SABC 法检测50 例ccRCC 及20 例癌旁正常 组织中CXCR4 和CXCR7 蛋白的表达。结果 ccRCC 组织中CXCR4 和CXCR7 表达高于癌旁正常组织 （P <0.05）；两者表达与ccRCC 组织的临床分期、病理分级及淋巴结转移关系密切（P <0.05），与性别、年 龄及肿瘤体积无关（P >0.05）；在ccRCC 组织中，CXCR4 与CXCR7 表达呈正相关（r s=0.467，P =0.001）。 结论 CXCR4 和CXCR7 在ccRCC 组织中呈高表达，两者对ccRCC 的发生、发展及转移有协同作用。

Abstract:

Objective To observe the expression of chemokine receptors 4 and 7 (CXCR4 and CXCR7) in renal clear cell carcinoma (RCC) and investigate their relationship. Methods The expressions of CXCR4 and CXCR7 proteins were detected by immunohistochemistry SABC method in 50 cases of RCC and 20 samples of paracancerous normal tissues. Results The expressions of CXCR4 and CXCR7 in the RCC were higher than those of the paracancerous tissues (P < 0.05). The expressions of CXCR4 and CXCR7 were closely related to clinical stage, degree of differentiation and lymph node metastasis (P < 0.05), and had no significant relationship with sex, age or tumor size (P > 0.05). The expression level of CXCR4 in the RCC was in positive correlation with CXCR7 (r s = 0.467, P = 0.001). Conclusions CXCR4 and CXCR7 proteins are highly expressed in RCC. They may play a synergistic effect in the occurrence and development of RCC.