乳腺癌患者肿瘤异常蛋白表达的影响因素研究

Expression of TAP in breast cancer patients and its influencing factors

摘要:

目的 分析肿瘤异常蛋白（TAP）在不同乳腺癌患者中的表达差异，探讨其影响因素及临床意 义。方法 选取该院2014 ～ 2016 年经手术确诊为乳腺癌的患者84 例，检测其末梢血涂片TAP 凝聚物面积， 比较不同临床病理特征患者TAP 表达的差异，分析TAP 在乳腺癌诊疗过程中的临床价值。结果 年龄≥ 65 岁患者的TAP 表达水平高于年龄<65 岁患者。淋巴结转移患者的TAP 表达水平高于无淋巴结转移患 者（P <0.05）。不同激素受体及人表皮生长因子受体乳腺癌患者的TAP 表达水平比较，差异无统计学意义 （P >0.05）。结论 不同年龄和有无淋巴结转移乳腺癌患者的TAP 表达水平有差异，具有临床应用价值，值得 进一步研究。

Abstract:

Objective To study the expression of tumor abnormal protein (TAP) in different types of breast cancer patients and explore its clinical value. Methods Eighty-four patients of breast cancer diagnosed by surgery in our hospital from 2014 to 2016 were selected. The area of TAP aggregates in peripheral blood smear was detected. The difference of TAP expression was compared among the patients with different clinicopathological characteristics, and the clinical value of TAP in diagnosis and treatment of breast cancer was analyzed. Results The expression of TAP in the patients ≥ 65 years of age was significantly higher than that of the patients <65 years (P < 0.05). The TAP expression of the patients with lymph node metastasis was also significantly higher than that of the patients without lymph node metastasis (P < 0.05). However, there was no significant difference in the TAP level among the patients with different expressions of ER, PR and HER-2 (P > 0.05). Conclusions The expression of TAP in breast cancer patients with different age and different lymph node metastatic status is significantly different. Detection of TAP has important clinical value.