中药在局部中晚期宫颈鳞癌中的应用研究

Role of traditional Chinese medicine in locally-advanced cervical squamous carcinoma

摘要:

目的 探究中药在局部中晚期宫颈鳞癌中的应用。方法 将124 例初发初治的Ⅱ b ～Ⅲ b 期宫 颈鳞癌患者随机分为中药联合治疗组和对照组，中药联合治疗组予以中药联合肿瘤深部热疗及同期放化疗； 对照组仅行肿瘤深部热疗及同期放化疗。比较两组治疗后的总有效率、生活质量、血清鳞状上皮细胞癌抗原 （SCC-Ag）、肝肾功能及不良反应。结果 两组治疗后SCC-Ag 水平比较有差异（P <0.05），两组治疗前后 的SCC-Ag 水平组间比较有差异（P <0.05），两组不良反应发生率比较有差异（P <0.05）。结论 中药联合 热疗及同期放化疗可提高局部中晚期宫颈鳞癌患者的生活质量，减轻不良反应。

Abstract:

Objective To explore the role of traditional Chinese medicine (TCM) in treatment of locallyadvanced cervical squamous cell carcinoma. Methods Totally 124 patients of stage Ⅱb-Ⅲb cervical squamous cancers were randomly divided into a combined TCM group (62 cases) and a control group (62 cases). The former group was treated with combined treatment which included TCM, thermotherapy and concurrent radiochemotherapy; the latter group received thermotherapy and concurrent radiochemotherapy. The total effective rate, the quality of life, serum level of squamous cell carcinoma antigen (SCC-Ag), hepatorenal functions and adverse reactions after treatments were compared. Results After treatment, the serum level of SCC-Ag was significantly different between the combined TCM group and the control group (P < 0.05). In both groups, the serum level of SCC-Ag was significantly different before and after treatment (P < 0.05). The incidences of adverse reactions were different between the two groups (P < 0.05). The KPS score in the combined TCM group was significantly higher than that in the control group (P < 0.05). However, there were no significant differences in the total effective rates or hepatorenal functions between the two groups (P > 0.05). Conclusions Traditional Chinese medicine combined with thermotherapy and radiochemotherapy can improve the quality of life and decrease the adverse reactions of the patients with locally-advanced cervical squamous carcinoma.