不明原因复发性流产孕妇检测狼疮抗凝物质和 同型半胱氨酸的意义

Clinical significance of screening lupus anticoagulant and homocysteine in unknown recurrent spontaneous abortion women

摘要:

目的 分析探讨狼疮抗凝物质（LA）、同型半胱氨酸（Hcy）及抗心磷脂抗体（ACA）在临床不明 原因复发性流产（URSA）孕妇中的应用价值。方法 选取89 例URSA 患者作为观察组和60 例非孕期正常妇 女为对照组。取外周血进行血浆LA 和血清Hcy、ACA 及叶酸（FA）水平检测统计分析。结果 与对照组相 比较，观察组LA、Hcy 及ACA 水平增高（P <0.05），而FA 水平降低（P <0.05）；观察组LA 水平与Hcy 水平呈 正相关（r =0.586，P =0.008）。结论 通过检测LA、HCY 等指标，对早期发现具有URSA 风险的患者并进行预 防性治疗。

Abstract:

Objective To investigate the application of screening lupus anticoagulant (LA), homocysteine (Hcy) and folic acid (FA) in recurrent spontaneous abortion pregnant women with unknown causes. Methods A total of 89 recurrent spontaneous abortion patients with unknown causes were enrolled in the URSA group, while another 60 non-pregnant healthy women were selected in the control group. Plasma levels of LA, Hcy, ACA and FA were measured. Results peripheral concentration of LA, Hcy and ACA increased while FA decreased significantly in URSA group when compared with control group (P < 0.05). Concentration of LA was positively correlated with Hcy in URSA (P < 0.05). Conclusion LA, Hcy and ACA may be promising diagnostic biomarkers for early discovery of URSA.