妇科肿瘤患者抗凝药物预防静脉血栓 栓塞的现况特点及合理性分析

Characteristics and rationality of anticoagulant drugs in prevention of venous thromboembolism in gynecological cancer patients

摘要:

目的 了解妇科恶性肿瘤使用抗凝药物预防静脉血栓栓塞（VTE）发生的现况特点，评价抗凝药物 的用药合理性。方法 采用随机抽样的方法，选取2016 年1 月1 日-2016 年12 月31 日某三甲综合医院及某肿 瘤专科医院收治的妇科恶性肿瘤住院患者1168 例次，进行回顾性调查分析。结果 该调查的1 168 份病历中， 预防性使用抗凝药物的病历共185 份，总预防用药率为15.84%（185/1168）。VTE 高危妇科恶性肿瘤住院患者 预防性抗凝用药率低，仅为32.32%。对使用抗凝药物防治VTE 的193 份病历进行评价，不合理用药病例数占 69.43%（134/193），主要为用药疗程不适宜。结论 妇科恶性肿瘤患者中使用抗凝药物预防VTE 所占比例较低， 并存在不合理使用现象。对VTE 高危的妇科恶性肿瘤患者，应积极采取预防性抗凝措施。

Abstract:

Objective To discover the characteristics and rationality of anticoagulant drugs in prevention of venous thromboembolism ingynecological cancer patients Methods A retrospective analysis of 1,168 cases of gynecologic malignant tumor hospitalized from January 1st, 2016 to December 31st, 2016 was made with random sampling method. Results A total of 185 cases preventively used anticoagulant drugs, the total prevention rate was 15.84% (185/1,168). The rate of prophylactic anticoagulation in hospitalized patients with gynecological malignancies who had high risk of venous thromboembolism was relatively low, only 32.32%. Totally 193 medical records of anticoagulant drugs for the prevention and treatment of venous thromboembolism were evaluated. The number of irrational drug use accounted for 69.43% (134/193), mainly for course of treatment was not appropriate. Conclusions The proportion of anticoagulant drugs used to prevent venous thromboembolism in patients with gynecologic malignancies is low, and there is unreasonable use in some cases. It should take some preventive anticoagulation measures positively for patients with gynecological malignancies who have high risk of venous thromboembolism.