MRI 参数与巨噬细胞炎性蛋白3α 和鼻咽癌 病理特征的关系

Analysis of MRI parameters and serum MIP-3α on pathological characteristics of nasopharyngeal carcinoma

摘要:

目的 通过MRI 增强扫描参数与检测血清巨噬细胞炎性蛋白3α（MIP-3α）在鼻咽癌患者中的 表达情况，探讨其在鼻咽癌诊断、与临床病理特征关系以及疗效评价中的作用。方法 应用定量ELISA 检测 120 例初治无远处转移的鼻咽癌患者血清MIP-3α 的表达和MRI 增强扫描参数情况。结果 120 例鼻咽癌患 者经过治疗后均达到完全缓解或部分缓解，鼻咽癌患者活检部位的MRI 动态参数与血清MIP-3α 表达呈正 相关（P <0.05）；鼻咽癌患者血清MIP-3α 水平高于健康对照者。不同T 分期、N 分期及临床分期患者的曲 线最大上升斜率比较，差异有统计学意义（P <0.05）；MIP-3α 与鼻咽癌临床分期相关，MIP-3α 还与T 分期 有关（P <0.05）。治疗后完全缓解患者的血清MIP-3α 降至健康对照者水平，部分缓解患者仍高于健康对照 者水平；鼻咽癌患者活检部位的MRI 动态参数与血清MIP-3α 表达呈正相关。结论 血清MIP-3α 水平作 为辅助诊断鼻咽癌的指标有一定的临床意义，其与磁共振增强扫描参数与检测有助于判断鼻咽癌分期和治疗 后的近期疗效。

Abstract:

Objective To study the effect of MRI enhancement scanning parameters and serum macrophage inflammatory protein-3 alpha (MIP-3α) expressed in nasopharyngeal carcinoma (NPC) on the diagnosis, pathological characteristics and therapeutic evaluation of NPC. Methods Quantitative Enzyme Lined Immunosorbent Assay (ELISA) was used to detect the expression of serum MIP-3α of 120 patients without distant metastasis of NPC and their MRI enhancement scanning parameters were also recorded. Results Totally 120 patients with NPC had total relief or partial relief after treatment. The dynamic parameters of MRI and serum MIP-3α had positive correlation with each other. Serum MIP-3α levels were significantly higher in patients with NPC than those in healthy controls. There were significant differences in the maximum slope of curve rise among patients with different T stage, N stage and clinical stage (P < 0.05). MIP-3α was associated with clinical stage and T stage of NPC. Serum MIP-3α level of patients with total relief after treatment was reduced to a healthy control level, while that of the ones with partial relief after treatment was higher than normal. The dynamic parameters of MRI in patients with NPC showed positive correlation with serum MIP-3α. Conclusion There is a clinical significance of serum MIP-3α level for the diagnosis of NPC. Serum MIP-3α combined with MRI enhanced scanning parameters can help to judge the stage of NPC and the short-term curative effect after treatment.