结直肠腺癌EGFR、CDX2 表达的 临床病理意义及相互关系

Expressions of EGFR and CDX2 in colorectal adenocarcinomas and clinicopathological significance

摘要:

目的 探讨结直肠腺癌组织中表皮生长因子受体（EGFR）及尾型同源框转录因子2（CDX2）蛋 白表达的临床病理意义。方法 收集结直肠腺癌标本170 例，采用免疫组织化学染色法检测EGFR 及CDX2 蛋白表达，分析其表达与结直肠腺癌临床病理参数之间的关系及意义。结果 结直肠腺癌EGFR 高表达率随 分化程度的降低逐渐增加；结直肠腺癌CDX2 高表达率在低分化、淋巴结转移及脉管内癌栓形成的患者中表 达降低，差异有统计学意义（P <0.05）。结论 EGFR 和CDX2 均参与结直肠腺癌的发生、发展，但两者参与 途径可能不同。

Abstract:

Objective To investigate the expressions of epidermal growth factor receptor (EGFR) and caudal type homeobox genes 2 (CDX2) in colorectal adenocarcinomas and their clinicopathological significance. Methods EGFR and CDX2 expressions in 170 samples of human colorectal adenocarcinomas were detected by immunohistochemical technique, and their correlations with clinicopathological parameters were analyzed. Results The positive expression rates of EGFR in the colorectal adenocarcinomas were gradually increased with the decrease of differentiation degree. The expression of CDX2 was correlated with differentiation degree, lymph node metastasis, and vascular tumor embolus formation of the colorectal adenocarcinomas (P < 0.05). Conclusions Both EGFR and CDX2 are involved in the occurrence and development of colorectal adenocarcinomas.