磁共振氢质子波谱成像对原发性 骨肉瘤的临床应用价值

Clinical value of 1H-magnetic resonance spectroscopy in diagnosis of osteosarcoma

摘要:

目的 探讨磁共振氢质子波谱成像（1H-MRS）对原发性骨肉瘤的临床应用价值。方法 选取 18 例临床资料完整并经病理证实的骨肉瘤患者行1H-MRS 检查，采用Spectroscopy 软件进行分析，得到基线 稳定的MRS 谱线、Cho 及Cho/Cr 值。结果 高、低度恶性骨肉瘤患者的Cho/Cr 值比较，差异有统计学意 义（P <0.05）。以Cho/Cr 作为诊断指标，最佳诊断界值为Cho/Cr=2.3。结论 1H-MRS 可用来评价骨肉瘤 的恶性程度。

Abstract:

Objective To explore the clinical value of 1H-magnetic resonance spectroscopy (1H-MRS) in osteosarcoma. Methods Eighteen cases were selected and examined by 1H-MRS scan, which had stable spectral lines, with the measurement parameters of Cho and Cho/Cr ratio. Results Cho/Cr ratio was significantly different between the high-grade and low-grade malignant osteosarcomas. As a diagnostic parameter, the best threshold value of Cho/Cr was 2.3. Conclusions 1H-MRS might be helpful for assessment of malignant degree of osteosarcoma.