尼古丁增强肺癌细胞耐药性与 Bcl-2 家族蛋白的关系

Relationship between nicotine-induced drug resistance and Bcl-2 family proteins in lung cancer cells

摘要:

肺癌是最常见的恶性肿瘤之一，长期吸烟是导致肺癌患者发生耐药及死亡的主要因素。尼古丁是 香烟烟雾中的主要成分，其可以影响肺癌细胞中B 细胞淋巴瘤/ 白血病2（Bcl-2）家族蛋白的表达，从而促进 癌细胞的生长，增强耐药性。本文主要阐述近年来尼古丁增强肺癌细胞耐药性与Bcl-2 家族蛋白关系的相关研 究。

Abstract:

Lung cancer is one of the most common malignancies. Long-term smoking is a major cause of drug resistance and death in patients with lung cancer. Nicotine is the main component of cigarette smoke, and can affect the expressions of Bcl-2 family proteins in lung cancer cells, thereby promote the growth of cancer cells and enhance their drug resistance. This review aims to summarize the related studies on the relationships between nicotineenhanced drug resistance and Bcl-2 family proteins in lung cancer in recent years.