冻融胚胎移植后早期血HCG 值 与妊娠结局的关系

Prediction of pregnant outcomes by serum β-HCG level after frozen-thawed embryo transfer cycle

摘要:

目的 探讨体外受精- 冻融周期胚胎移植后7 和14 d 单次血人绒毛膜促性腺激素（HCG）水平 对妊娠结局的预测价值。方法 回顾性分析2016 年1 月-2017 年1 月于山东中医药大学附属医院生殖中心 行冻融周期胚胎移植后255 例妊娠患者的临床资料。按妊娠结局分为正常妊娠组（单胎持续妊娠组、双胎持 续妊娠组），异常妊娠组（异位妊娠组、单胎停育组）。比较各组移植后7 和14 d 血清HCG 的水平，并对结 果进行比较分析。结果 正常妊娠组的7 和14 d 血清HCG 均高于异常妊娠组（P <0.05）；单胎停育组与单 胎持续妊娠组7 d 血清HCG 比较，差异无统计学意义（P >0.05）；单胎停育组14 d 血清HCG 低于单胎持续 妊娠组（P <0.05）。结论 移植后7、14 d 血清HCG 水平对预测早期妊娠结局都有较好的临床意义，且14 d 血清β-HCG 水平预测价值更高。

Abstract:

Objective To investigate the value of single serum human chorionic gonadotropin (β-HCG) level on day 7 and 14 after in vitro fertilization and frozen-thawed embryo transfer cycle (IVF-FET) in prediction of pregnant outcomes. Methods A retrospective analysis was performed on 255 pregnant patients, who were transferred with frozen-thawed embryos in the Reproductive Center of the Affiliated Hospital, Shandong University of Traditional Chinese Medicine between January 2016 and January 2017. According to the outcomes of pregnancy they were divided into a normal pregnancy group (including a single continued pregnancy subgroup and a twins continued pregnancy subgroup), and an abnormal pregnancy group (including an ectopic pregnancy subgroup and a single non-viable pregnancy subgroup). The level of serum β-HCG was analyzed on the 7th and 14th days after transplantation (abbreviated as HCG7d, HCG14d), and the results were analyzed. Results The HCG7d and HCG14d of the normal pregnancy group were higher than those of the abnormal pregnancy group (P < 0.05). There was no significant difference in HCG7d between the single non-viable pregnancy subgroup and the single continued pregnancy subgroup (P > 0.05). The HCG14d of the single nonviable pregnancy subgroup was lower than that of the single continued pregnancy subgroup (P < 0.05). Conclusions The quantitative determination of serum β-HCG on days 7 and 14 after FET might be of some value in prediction of early pregnant outcomes, and the serum β-HCG on day 14 has higher predictive value.